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GSBS Research Topics: VIROLOGY


Scott R. Diehl, Ph.D. * - Newark - Single Nucleotide Polymorphisms (SNPs) are analyzed to understand molecular causes of disease and individual differences in drug responses. High-throughput bioinformatics and complex statistical genetic methods are used for current research on oral cancer, periodontal disease, orofacial clefting; pharmacogenomics of pain and drug responses.

Joseph P. Dougherty, Ph.D. * - Piscataway - Retroviral replication and the design and use of retroviral vectors for somatic cell gene therapy, studies of retroviral mutation using retroviral vectors and packaging cells, and murine model for somatic cell gene therapy.

Patricia Fitzgerald-Bocarsly, Ph.D. * - Newark - Studies on the inate immune response to viral infection are focused on a dendritic cell subpopulation (DC2) that produces interferon-alpha in response to viral stimulation. Mechanisms of viral induction of IFN in these cells and their interactions with natural killer cells, and T helper cells are under investigation.

Abram Gabriel, M.D. * - Piscataway - My laboratory focuses on the study of mechanisms and consequences of retrotransposon reverse transcription.

Lisa Huang, Ph.D. * - Stratford - My current research focuses on the identification of cancer biomarkers in the diagnosis and monitoring of cervical cancer, bladder cancer, and prostate cancer. Another of my research focuses on studying the mechanisms of DNA repair and drug resistance in bladder cancer and prostate cancer. These researches aid to assist in novel drug discovery. Email: lhuang@mdlab.com

M. Zafri Humayun, Ph.D. * - Newark - We study mechanisms of genetic variability in Escherichia coli and in the pathogen Helicobacter pylori. We have recently defined two novel transient mutator pathways termed UVM and TSM pathways. The TSM pathway reveals unanticipated links among translation, DNA replication and recombination. Antibiotics, helicase.

Neerja Kaushik-Basu, Ph.D. * - Newark - My lab is studying the molecular mechanisms of Hepatitis C Virus Replication and Pathogenesis with specific reference to its non-structural protein NS5B and its RNA. In addition, we are studying the structure-function inter-relation of the SARS virus replicase.

Fred R. Kramer, Ph.D. * - Newark - RNA replication, RNA structure, recombinant RNA, nucleic acid probes, molecular beacons, oligonucleotide arrays

Jerome A. Langer, Ph.D. * - Piscataway - Our interests include how diverse Type I interferons are differentially recognized by a common cell surface receptor and sometimes initiate different cellular responses. We are also examining cellular responses to flaviviruses, particularly dengue virus.

Michael J. Leibowitz, Ph.D. * - Piscataway - Study of therapeutic agents acting on RNA targets to inhibit Tat-mediated transactivation in HIV-1 and group I intron ribozymes of fungi; epigenetic regulation of viral gene expression; polymeric drug delivery systems. Antibiotics.

John Lenard, Ph.D. * - Piscataway - Function of cholesterol in the development and reproduction of the multicellular organism C. elegans. A combination of genetic, biochemical and microscopic techniques are used to understand the processes of hormone biosynthesis, transport and action at a cellular and molecular level.

David M. Lukac, Ph.D. * - Newark - Molecular virology of Kaposi`s sarcoma-associated herpesvirus (HHV-8) in the pathogenesis of Kaposi`s sarcoma and primary effusion lymphoma.

Michael B. Mathews, Ph.D. * - Newark - The regulation of HIV transcription. We are studying how the essential HIV Tat protein activates transcription and regulates the course of viral infection by interacting with cellular proteins, most notably a transcription elongation factor called P-TEFb or CDK9/cyclin T.

Harvey Ozer, M.D. * - Newark - Carcinogenesis and Regulation of Cellular Aging. We have been studying human diploid fibroblasts (HF) and introduction of genes from the DNA tumor virus SV40 to understand the mechanism of multi-step carcinogenesis ("transformation") in culture and its effect on bypassing cellular aging and facilitating immortalization.

Sidney Pestka, M.D. * - Piscataway - Research involves the cloning of interferons and their receptors, and the development of new strategies for the treatment of viral diseases and cancers. The studies involve interferon and cell surface receptors and revolve around genetic engineering, protein biochemistry, signal transduction, immunology and gene therapy.

Arnold B. Rabson, M.D. * - Piscataway - Our laboratory studies the molecular virology of HIV/AIDS and HTLV with a focus on regulation of viral gene expression. A second focus is the role of transcription factors in cancer and oncogenesis, particularly in lymphomas and prostate cancer.

Monica Roth, Ph.D. * - Piscataway - Retroviruses, integration, reverse transcriptase, RNase and envelope proteins.

Aaron Shatkin, Ph.D. * - Piscataway - Mechanisms of eukaryotic gene expression: initiation of viral and cellular transcription and translation; roles of mRNA 5`terminal cap and cap-binding proteins; protein:protein interactions linking capping to protein transport and mRNA biogenesis.

Victor Stollar, M.D. * - Piscataway - Replication of mosquito-transmitted RNA viruses in cell-fusing agent); viral genetics, host-range viral mutants; expression and characterization of virus-coded methyltransferases.

Nancy, A. Woychik, Ph.D. * - Piscataway - RNA polymerases and transcription regulation in cancer and other diseases; Alterations in host cell transcription upon smallpox virus infection; Transcription mechanisms important for Chlamydia pathogenesis; Chlamydia infection and heart disease.

Hua Zhu, Ph.D. * - Newark - My lab is studying cytomegalovirus, including host responses to viral infection, i.e. changes of signal transduction, and to understand how these responses influence viral replication and pathogenesis, and use microarray and mass spectrometry technologies to study viral and cellular gene expression.

* GSBS Faculty Return to Topics list


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