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GSBS Research Topics: SIGNAL TRANSDUCTION


Beverly E. Barton, Ph.D. - Newark - We are studying the role of IL-6-like cytokines and signal transduction in prostate cancer. Using approaches from immunology, e.g. flow cytometry to measure activated signaling proteins, we have demonstrated the activation of STAT3 in neoplastic but not hyperplastic prostate cells.

Joshua R. Berlin, Ph.D. * - Newark - Voltage-dependent reaction steps in ion transport using the Na,K-ATPase as a model system. Ion transport kinetics are measured by patch-clamp in cardiac myocytes and HeLa cells expressing Na,K-ATPase enzymes containing point mutations. We also are studying Cardiac muscle excitation-contraction coupling and calcium influx.

Subal C. Bishayee, Ph.D. * - Newark - We are interested in receptor tyrosine kinase-mediated signal transduction and how aberrant expression of these receptors leads to altered signaling in cancer. We are also interested in structure-function relationship of these proteins, particularly after their phosphorylation.

George M. Carman, Ph.D. * - Piscataway - Membrane phospholipid synthesis in the yeast Saccharomyces cerevisiae. Phospholipids serve as signaling molecules and reservoirs of lipid messengers. We are examining the role of lipid phosphate phosphatases in cell signaling and the roles protein kinases A and C play in the regulation of phospholipid synthesis.

Rocco V. Carsia, Ph.D. * - Stratford - Research is aimed at elucidating the cellular and molecular events regulating the remodeling of the reptilian adrenal gland. Influences of sex, season and various stressors on reptilian adrencortical cell function are evaluated. A variety of lizard species is used. Email: carsiaro@umdnj.edu

Patrizia Casaccia-Bonnefil, M.D., Ph.D. * - Piscataway - Proliferation and differentiation of CNS precursor cells. Apoptosis mediated by death receptors in oligodendrocytes. Role of cell cycle inhibitors (p27,p21,p57) in CNS. Cancer. Multiple sclerosis. Stem Cells.

Nancy D. Connell, Ph.D. * - Newark - Using a combined approach of bacterial genetics and cell biology, we study the interaction of Mycobacterium tuberculosis with its host cell, the macrophage. We use mutants of this important pathogen to study intracellular amino acid and peptide metabolism within mouse and human macrophages. Antibiotics.

Earlene B. Cunningham, Ph.D. * - Newark - Characterization and cloning a novel (human) plasma membrane-associated immunophilin (a signal transduction protein targeted by certain drugs used to prevent the rejection of organ transplants). This 12 kDa IP3-, IP4-, and phosphatidylinositol phosphate-binding protein has been named IPBP12.

Gill Diamond, Ph.D. * - Newark - Studies on the molecular biology and mechanisms controlling expression of antimicrobial peptides, especially under conditions of injury, stress and infection. These peptides are found in phagocytic cells and mucosal tissues and may help us better understand host defense mechanisms. Antibiotics.

David Dubnau, Ph.D. * - Newark - Research concerns regulation of competence and mechanism of DNA transport in Bacillus subtilis.

Member, Public Health Research Institute and Professor, Department of Microbiology and Molecular Genetics. Located in ICPH building, 225 Warren Street, Newark, NJ 07103.

Isaac Edery, Ph.D. * - Piscataway - We use Drosophila melanogaster as a model system to understand the molecular underpinnings governing circadian rhythms. Our main goals are to understand how a circadian oscillator is assembled and how it responds to environmental cues, most notably visible light and ambient temperature.

Patricia Fitzgerald-Bocarsly, Ph.D. * - Newark - Studies on the inate immune response to viral infection are focused on a dendritic cell subpopulation (DC2) that produces interferon-alpha in response to viral stimulation. Mechanisms of viral induction of IFN in these cells and their interactions with natural killer cells, and T helper cells are under investigation.

Stephen Garrett, Ph.D. * - Newark - We are interested in mechanisms of cell sensing. Our studies are carried out in the yeast Saccharomyces cerevisiae and are currently directed toward elucidating the function of the second messenger cAMP, as well as understanding the mechanism of manganese homeostasis.

Gary, S. Goldberg, Ph.D. - Stratford - Cells must communicate with each other to coordinate the development and survival of an animal. This communication can be mediated by diffusible factors that pass between cells, or by direct contact through cell junctions. I am interested in how intercellular communication affects cell growth and differentiation, with an emphasis on how cell communication can control tumor cell growth and prevent eye diseases. Email: gary.goldberg@umdnj.edu

Beatrice Haimovich, Ph.D. * - Piscataway - i) Elucidation of signaling events and identification of tyrosine phosphorylated proteins that regulate platelet spreading, ii) Host responses to biomaterials.

William, N. Hait, M.D., Ph.D. * - Piscataway - Identification of genetic determinants of drug sensitivity in cancer; new targets, signal transduction pathways; oncogenes; translation into genomics based clinical trials.

Carl J. Hauser, M.D. - Newark - My laboratory studies neutrophil functional responses in the inflammatory cytokine milieu generated by trauma. We have a special interest in the cross regulation of G-protein coupled receptors and the mechanisms of their mobilization of cell calcium under such conditions.

Utz Herbig, Ph.D * - Newark - Our laboratory is interested in understanding how telomeres contribute cellular senescence in mammalian cells. As cellular senescence is a critical tumor suppressing mechanism, but also is thought to contribute to organismal aging, our studies are relevant for both aging- and cancer-research.

Richard D. Howells, Ph.D. * - Newark - Molecular analysis of opioid receptor structure and function. Opioid receptors are G protein-coupled receptors on the cell surface of neurons that mediate signal transduction pathways activated by endogenous opioid peptides and opiate drugs, such as morphine. Molecular consequences of opioid addiction are being investigated via gene arrays and proteomics.

Lisa Huang, Ph.D. * - Stratford - My current research focuses on the identification of cancer biomarkers in the diagnosis and monitoring of cervical cancer, bladder cancer, and prostate cancer. Another of my research focuses on studying the mechanisms of DNA repair and drug resistance in bladder cancer and prostate cancer. These researches aid to assist in novel drug discovery. Email: lhuang@mdlab.com

Sumiko Inouye, Ph.D. * - Piscataway - Development-specific gene expression, signal transduction during differation, eukaryotic-like protein kinases, bacterial retroelements, reverse transcritase.

Masayori Inouye, Ph.D. * - Piscataway - Molecular biology of cellular adaptation to stresses (1)transmembrane signal transduction by protein histidine kinases; (2)cold-shock response and adaptation; (3)developmental signal transduction in Myxococcus xanthus; (4)GTP metabolism; (5) protein folding; (6)bacterial retroelements.

Ken Irvine, * - Piscataway - The primary focus of our research is the regulation of patterning and growth during animal development, with a particular emphasis on Notch signaling. Our work takes advantage of the powerful genetic, molecular and cellular techniques available in Drosophila, which facilitate both gene discovery and the analysis of gene function.

Neerja Kaushik-Basu, Ph.D. * - Newark - My lab is studying the molecular mechanisms of Hepatitis C Virus Replication and Pathogenesis with specific reference to its non-structural protein NS5B and its RNA. In addition, we are studying the structure-function inter-relation of the SARS virus replicase.

Eldo, V. Kuzhikandathil, Ph.D. * - Newark - We are interested in the molecular analysis of dopamine receptor signaling mechanisms and their role in neurological diseases.Current research projects include structure-function analysis of dopamine receptors and the developmental regulation of dopamine receptor signaling pathways.

Deborah, A. Lazzarino, Ph.D. * - Newark - Research studies in stem cell biology of the mammary gland in both normal and oncogenic development.

Robert W. Ledeen, Ph.D. * - Newark - 1. Ganglioside and sphingolipids in neuronal function: cell membrane and nuclear membrane. 2. Gangliosides as modulators of flux and signaling. 3. Myelin metabolism in multiple sclerosis and normal brain. Myelin receptors for cytokines. 4. N-Acetylaspartate and myelinogenesis.

Chee-Gun Lee, Ph.D * - Newark - The role of RNA helicase A (RHA) in transcription. Functioning as both DNA and RNA helicase, the RHA is also able to associate with dsDNA and nucleosome without any significant difference. Our findings implicate RHA in the development and/or progress of prostate cancer as a factor important for a crosstalk between STAT- and AR-mediated transcription pathways.

Hong Li, Ph.D. * - Newark - Center for Advanced Proteomics Research is located in MSB F602 at NJMS. This facility is equipped with state-of-the-art proteomics instruments and bioinformatics systems for protein structure and function analysis. We have a Micromass QTOF mass spectrometer and an ABI 4700 Proteomics Analyzer.

David M. Lukac, Ph.D. * - Newark - Molecular virology of Kaposi`s sarcoma-associated herpesvirus (HHV-8) in the pathogenesis of Kaposi`s sarcoma and primary effusion lymphoma.

Stuart G. Lutzker, M.D., Ph.D. * - Piscataway - My lab examines the role of the p53 transcription factor in the cellular response to DNA damage. We have developed a unique genetic system to test the role of specific post-translational modifications in fine-tuning the p53 response.

Kiran Madura, Ph.D. * - Piscataway - Ubiquitin-mediated protein degradation in DNA repair and signal transduction.

Randall D. McKinnon, Ph.D. * - Piscataway - Oligodendrocyte development; transplantation analysis of primary OL progenitor cells engineered to be non-responsive to specific factors using dominant-negative receptor constructs; signal transduction by receptors with intrinsic catalytic protein tyrosine kinase activity; gene expression analysis using microarray chip technology.

Carlos A. Molina, Ph.D. * - Newark - We are interested in the regulation of gene expression during the cell cycle by the tumor suppressor and transcriptional repressor, Inducible cAMP Early Repressor (ICER). Circadian rhythm.

Catherine Neary, Ph.D. * - Stratford - Hexokinase II (HK2), which catalyzes the first committed step of glycolysis, is overexpressed in many cancers. When inhibited, HK2 translocates from the mitochondria to the nucleus. I am investigating the signaling pathways that mediate HK2 mitochondrial association and nuclear translocation. Email: nearycl@umdnj.edu

Joseph Nickels, Ph.D. * - Stratford - Our research uses proteomic/genomic methods and mouse models to understand the biology of diseases, such as cancer initiation and metastasis, cardiovascular disease, and infectious mycoses. Our goal is discovering novel genes that can be used as biomarkers and drug targets, thus allowing us to diagnose and treat these diseases. Email: jnickels@mdlab.com

Martha C. Nowycky, Ph.D. * - Newark - We study voltage-gated calcium channels and the TRP family channels, using patch clamp, digitial imaging, and molecular biology techniques. We examine the links between neurotransmitter and hormone stimulation, signal transduction via G-proteinsand calcium stores in neurons and excitable cells.

Harvey Ozer, M.D. * - Newark - Carcinogenesis and Regulation of Cellular Aging. We have been studying human diploid fibroblasts (HF) and introduction of genes from the DNA tumor virus SV40 to understand the mechanism of multi-step carcinogenesis ("transformation") in culture and its effect on bypassing cellular aging and facilitating immortalization.

Nicola C. Partridge, Ph.D. * - Piscataway - Parathyroid hormone signal transduction pathways regulating transcription of collagenase or stimulating osteoblast cell proliferation. Endocytotic receptors mediating the degradation of secreted collagenase. Mechanisms for enhancing the degradation of collagenase in osteoarthritic chondrocytes.

John Pastorino, PhD * - Stratford - Our work identifies distinctions in mitochondrial function between normal and cancerous cells for the potential discovery of novel chemotherapeutic targets that can be exploited to selectively induce cytotoxicity in cancer cells. Mitochondrial injury is also central to number of disease states. Email: pastorjg@umdnj.edu

Garth I. Patterson, Ph.D. * - Piscataway - We study a TGF-beta pathway that controls C. elegans larval development. We wish to learn how this pathway controls a neuroendocrine signal, as well as how this signal is transduced.

Sidney Pestka, M.D. * - Piscataway - Research involves the cloning of interferons and their receptors, and the development of new strategies for the treatment of viral diseases and cancers. The studies involve interferon and cell surface receptors and revolve around genetic engineering, protein biochemistry, signal transduction, immunology and gene therapy.

Melissa B. Rogers, Ph.D. * - Newark - Retinoids control cell cycle, apoptosis, & differentiation. We study how retinoic acid controls key genes like BMP-2. We use enhancer traps to isolate RA response elements. Our functional genomics approach should identify RA-regulated genes that initiate critical signaling cascades in development.

Christopher Rongo, Ph.D. * - Piscataway - We study how different neurotransmitter receptor types are sorted to the appropriate synapses in a neuron and how synapses in the central nervous system change in the growing animal. By using genetic screens, behavioral analysis, and molecular and cell biological techniques in C. elegans, we hope to identify the proteins that build and regulate synapses.

Vanessa H. Routh, Ph.D. * - Newark - Central regulation of glucose homeostasis. Electrophysiological and PCR studies of brain slices and isolated neurons in a rodent model of diet-induced obesity and type II diabetes mellitus. Focus on mechanisms by which neurons respond to physiologic changes in extracellular glucose, as well as regulation of glucosensing neurons.

Alexey, G. Ryazanov, Ph.D. * - Piscataway - We are studying the structure and function of a novel class of protein kinases that we recently discovered. These kinases are involved in the regulation of many biological processes including calcium influx, protein synthesis and aging. We are using C. elegans and mice as model systems.

Nithianandan Selliah, Ph.D. * - Stratford - Research focus is to identify biomarkers in autoimmune diseases (SLE and IBD) with particular emphasis on T-cell & B-cell activation signaling. Secondary interest is to identify novel signaling pathways in prostate cancer cells and develop targets for therapy. Email: N.Selliah@Humigen.org

Natalia Shcherbik, Ph.D. * - Stratford - We currently focus on elucidating the mechanisms of ribosome turnover using Saccharomyces cerevisiae as a model system. We are particularly interested in the role of ubiquitination in controlling the activity of ribonucleases that target ribosomes and how this process in regulated in the cell. Email: shcherna@umdnj.edu

Yufang Shi, Ph.D., D.V.M. * - Piscataway - We are interested in understanding the role of apoptosis in regulating immune responses. The mechanisms controlling FASL, TRAIL, RANKL and TNF expression in T cells are the main focus. We are also studying psychoneuroimmunology, especially the effects of stress and opioids on the immune system.

Andrew Singson, Ph.D. - Piscataway - The goal of research in the lab is to understand the molecular events that mediate sperm-egg interactions. The genetic and molecular dissection of these events will also provide insights relevant to other important cell-cell interactions in multicellular organisms.

Zoltan Spolarics, M.D., Ph.D. * - Newark - The project investigates the effects of genetic polymorphisms of metabolic enzymes and cytokines (IL-6, IL-10, IFN-γ) on the immune response. We employ genetically modified mice using experimental models of infection in vivo. We also investigate macrophage and T-cell responses in vitro. The human component of the project investigates the effects of genetic polymorphisms on the immune response in trauma patients. Infection, immunity, T-cells, macrophages, red blood cells, chemokines, polymorphism, flow cytometry, injury, host-response, malaria.

Ann M. Stock, Ph.D. * - Piscataway - We study bacterial signal transduction using a combination of molecular genetic, biochemical, and X-ray crystallographic methods to study structure and function of signaling proteins. We study the role of reversible protein modification and protein-protein interactions in signaling pathways.

Ann M. Stock, Ph.D. * - Piscataway - Structure & function analysis of signal transduction proteins and the role of protein modifications such as phosphorylation and methylation. Projects include unusual mammalian protein kinases and bacterial pathogenesis. Studies employ molecular genetics, biochemistry and X-ray crystallography.

George P. Studzinski, M.D.,Ph.D. * - Newark - With the objective of advancing cancer chemotherapy options,we are studying the mechanisms of induction of mature monocytic phenotype and cell cycle arrest in human myeloid leukemia cells(HL60,U937,etc).Analogs of vitamin D are principal inducing agents,and MAPK and PI3K pathways are the current focus.

Andrew P. Thomas, Ph.D. * - Newark - 1) Calcium-dependent signal transduction in response to hormones and growth factors, and 2) the effects of cocaine and alcohol on cardiac excitation-contraction coupling. We use digital imaging and laser scanning confocal microscopy to measure calcium and monitor organelle function in living cells; ion channel electrophysiology; molecular biology.

Ellen Townes-Anderson, Ph.D. * - Newark - Using primary cultures, we are trying to understand mechanisms of regeneration, degeneration, and synaptic plasticity in photoreceptors and other types of retinal neurons. Techniques used include microscopy, optical tweezers, time lapse recording, immunocytochemistry, and molecular biology.

Jason Trama, Ph.D. * - Stratford - Our laboratory uses proteomic and genomic data to identify biomarkers for gynecologic and urologic cancers. Our goal is to develop noninvasive methods for diagnosis and monitoring. We also study the mechanisms of tumorigenesis, metastasis and drug resistance in order to identify targets for therapy. Email: jtrama@mdlab.com

Venkat Venkataraman, Ph.D * - Stratford - We are investigating the processes of neuronal transduction in biological clocks and aging with respect to the role of Ca2+ signaling via alpha2 adrenergic receptors and membrane guanylate cyclases. Email: venkatar@umdnj.edu

B.J. Wagner, Ph.D. * - Newark - Role of the ubiquitin-proteasome pathway in development, aging and response to stress: We use the mammalian ocular lens and lens cell culture models to study differentiation, cataractogenesis and oxidative stress.

Nancy Walworth, Ph.D. * - Piscataway - Studies on cell cycle checkpoints: signal transduction pathways that control cell cycle progression in response to DNA damage or DNA replication blocks, using the genetically tractable fission yeast, Schizosaccharomyces pombe as a model system. Checkpoint defects are apparent in cells of patients with the cancer-prone genetic disorder ataxia telangiectasia (AT).

Ian P. Whitehead , Ph.D. * - Newark - Our laboratory examines mammalian signal transduction and its relationship to cancer. More specifically, we utilize highly efficient, retroviral-based expression systems to identify and characterize oncogenes whose expression contribute to the metastatic potential of human breast tumors.

Lizhao Wu, Ph.D. * - Newark - We use a combination of molecular, cellular, and genetic approaches to identify key molecules that are important for cancer. Both cell culture systems and mouse models are used to delineate various tumor suppressor/oncogenic pathways in the hematopoietic system, prostate gland, and mammary gland.

Jiang H. Ye, M.D. * - Newark - Patch-clamp electrophysiological techniques combined with pharmacological tests are used on neurons in brain slices and acutely isolated (enzymatically and mechanically) neurons in attempt to understand the cellular and molecular mechanisms underlying: 1) general anesthetics, and 2) alcohol addiction.

James Zheng, Ph.D. * - Piscataway - We are interested in the molecular and cellular mechanisms underlying the precise wiring of the complex nervous system. Our current work focuses on the intracellular signaling pathway that allows developing axons to detect direction from environmental cues to reach their targets for specific neuronal connections.

Hua Zhu, Ph.D. * - Newark - My lab is studying cytomegalovirus, including host responses to viral infection, i.e. changes of signal transduction, and to understand how these responses influence viral replication and pathogenesis, and use microarray and mass spectrometry technologies to study viral and cellular gene expression.

* GSBS Faculty Return to Topics list


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