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Vivian Bellofatto, Ph.D. * - Newark - Our laboratory is investigating the transcriptional mechanisms that trypanosomes use to direct and modulate gene expression. Trypanosomes are parasitic protozoa which cause a multitude of diseases around the world. We have identified novel transcription factors in these parasites.

Gary Brewer, Ph.D. * - Piscataway - Identification and analyses of cis- and trans-acting factors controlling mRNA decay in cancer, heart disease and immune responses.

Isaac Edery, Ph.D. * - Piscataway - We use Drosophila melanogaster as a model system to understand the molecular underpinnings governing circadian rhythms. Our main goals are to understand how a circadian oscillator is assembled and how it responds to environmental cues, most notably visible light and ambient temperature.

Ronald Ellis, Ph.D. * - Stratford - Control of Germ Cell Fate: Animals must produce sperm or eggs to reproduce. Although these cell types differ dramatically, they are produced from similar progenitors. Understanding how this process is controlled could revolutionize our ability to treat reproductive disorders and infertility in humans. Evolution of Hermaphroditism: Sexual traits are among the most rapidly changing features of each species. To learn how these changes take place, and how developmental pathways constrain which ones occur, we are studying the evolution of mating systems in nematodes. Email: ellisre@umdnj.edu

Michael F. Henry, Ph.D. * - Stratford - We use the yeast Saccharomyces cerevisiae as a model system to understand the molecular mechanisms by which RNA precursors are processed in the nucleus. More precisely, our goal is to understand the role of posttranslational protein modification in this process. Email: henrymf@umdnj.edu

Hristo Houbaviy, Ph.D. * - Stratford - We are interested in the roles of microRNAs in embryonic stem (ES) cells and during the early development of the mouse. Specifically, we are applying biochemical and mouse model approaches to elucidate the functions of miR-290-295 / miR-371-373 which appear to be ES cell and early embryo specific. Email: houbavhr@umdnj.edu

M. Zafri Humayun, Ph.D. * - Newark - We study mechanisms of genetic variability in Escherichia coli and in the pathogen Helicobacter pylori. We have recently defined two novel transient mutator pathways termed UVM and TSM pathways. The TSM pathway reveals unanticipated links among translation, DNA replication and recombination. Antibiotics, helicase.

Fred R. Kramer, Ph.D. * - Newark - RNA replication, RNA structure, recombinant RNA, nucleic acid probes, molecular beacons, oligonucleotide arrays

David M. Lukac, Ph.D. * - Newark - Molecular virology of Kaposi`s sarcoma-associated herpesvirus (HHV-8) in the pathogenesis of Kaposi`s sarcoma and primary effusion lymphoma.

Carol S. Lutz, Ph.D. * - Newark - We are interested in how eukaryotic gene expression is regulated at the level of mRNA processing, particularly in splicing and polyadenylation. Some of the protein factors involved are autoantigens in patients with lupus, and we are also interested in understanding this phenomenon.

Dmitriy Markov, Ph.D. * - Stratford - My research is focused on regulation of mitochondrial transcription and transcription-coupled processes and how they change in response to oxidative stress in neuronal tissue. Email: markovdm@umdnj.edu

William McAllister, Ph.D * - Stratford - Molecular basis of transcription. Work in our laboratory concerns the structure and function of RNA polymerase, the enzyme that carries out the first step in gene expression, using a combination of biochemical, genetic, and structural methods. Email: mcalliwt@umdnj.edu

Eric G. Moss, Ph.D. * - Stratford - We study developmental timing, microRNAs and translational control in C. elegans and the mouse. The worm heterochronic gene lin-28 is regulated by microRNAs and encodes a specific mRNA-binding protein. Its human homologue, Lin28, appears also to be a microRNA-controlled developmental regulator. Email: mosseg@umdnj.edu

Smita Patel, Ph.D. * - Piscataway - Understanding the enzymatic mechanisms of DNA helicase, RNA helicase, primase, and RNA polymerase proteins.

Sidney Pestka, M.D. * - Piscataway - Research involves the cloning of interferons and their receptors, and the development of new strategies for the treatment of viral diseases and cancers. The studies involve interferon and cell surface receptors and revolve around genetic engineering, protein biochemistry, signal transduction, immunology and gene therapy.

Dimitri G. Pestov, PhD * - Stratford - We study the mechanisms of ribosome biogenesis in mammalian cells in connection with regulation of cell growth and proliferation. Our major goal is to understand how the accuracy of ribosome assembly is controlled at the molecular level and how defects in this process contribute to human disease. Email: pestovdg@umdnj.edu

Aaron Shatkin, Ph.D. * - Piscataway - Mechanisms of eukaryotic gene expression: initiation of viral and cellular transcription and translation; roles of mRNA 5`terminal cap and cap-binding proteins; protein:protein interactions linking capping to protein transport and mRNA biogenesis.

Natalia Shcherbik, Ph.D. * - Stratford - We currently focus on elucidating the mechanisms of ribosome turnover using Saccharomyces cerevisiae as a model system. We are particularly interested in the role of ubiquitination in controlling the activity of ribonucleases that target ribosomes and how this process in regulated in the cell. Email: shcherna@umdnj.edu

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