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Mikhail Anikin, Ph.D * - Stratford - Research in the laboratory is focused on the structure-function relationships in RNA polymerase transcription complexes. Our model transcription systems are based mostly on single-subunit enzymes, such as mitochondrial RNA polymerases and T7 RNA polymerase. Email: anikinmi@umdnj.edu

Helen M. Berman, * - Piscataway - Our goal is to understand the structural properties of biological molecules and to relate these structures to their biological functions. Projects include the Protein Data Bank, the Nucleic Acid Database, and X-ray crystallographic and molecular modelling studies of biological molecules.

Subal C. Bishayee, Ph.D. * - Newark - We are interested in receptor tyrosine kinase-mediated signal transduction and how aberrant expression of these receptors leads to altered signaling in cancer. We are also interested in structure-function relationship of these proteins, particularly after their phosphorylation.

Sergei Borukhov, Ph.D * - Stratford - We are focusing our studies on the structure and function of prokaryotic multisubunit RNA polymerase, and on analysis of molecular mechanism of action and biological role of transcription factors Gre and their homologs. Email: borukhse@umdnj.edu

Kenneth J. Breslauer, Ph.D. * - Piscataway - Characterization of the molecular interactions that control biopolymer structure and stability, drug-binding affinity and specificity, relating biophysical properties to biological function, correlating structure and energetics.

Barbara M. Brodsky, Ph.D. * - Piscataway - Biophysical studies on peptides which model the collagen triple-helix in various collagen types as well as in C1q, collectins, and the macrophage scavenger receptor. The effects of mutations found in genetic diseases are characterized.

Barbara Brodsky, Ph.D. * - Piscataway - Structural studies on triple-helix proteins

Andrew L. Harris, Ph.D. * - Newark - Connexins form intercellular pores through which ions and signaling molecules pass directly from cell to cell. These pores are important in signal transduction, tissue function, development and disease. Our studies explore, at the molecular level, mechanisms of selective molecular permeation, and mechanisms that regulate channel gating.

John, E. Kerrigan, Ph.D. * - Piscataway - Our research efforts are aimed toward the identification of novel small molecule therapetics for the treatment of cancer and other diseases using de novo computational methods. Molecular modeling of protein and dna complexes with potential drug leads is applied.

Terri Goss Kinzy, Ph.D. * - Piscataway - Our lab studies the mechanism and regulation of protein synthesis and general principles of G-protein regulation. Research areas include mutational, genetic and structural analysis of translation factors and related G-proteins and their potential roles in oxidative stress and other cell processes.

Fred R. Kramer, Ph.D. * - Newark - RNA replication, RNA structure, recombinant RNA, nucleic acid probes, molecular beacons, oligonucleotide arrays

Muriel W. Lambert, Ph.D. * - Newark - Research is ongoing on DNA repair mechanisms, in particular in cells from patients with genetic diseases with repair defects. The genes and proteins involved are being studied as is the interaction of these proteins with damaged DNA and damaged chromatin.

Hong Li, Ph.D. * - Newark - Center for Advanced Proteomics Research is located in MSB F602 at NJMS. This facility is equipped with state-of-the-art proteomics instruments and bioinformatics systems for protein structure and function analysis. We have a Micromass QTOF mass spectrometer and an ABI 4700 Proteomics Analyzer.

Narayanan Ramasubbu, Ph.D. - Newark - Structural biology of proteins that impact oral diseases and biofilms.

Roman Shirokov, Ph.D. * - Newark - Ca channels interface membrane excitability and Ca signaling. We study their inactivation, or spontaneous disabling closure. We measure ionic and gating currents, intracellular Ca signals. We use molecular engineering and bioinformatics to define the structure and interactions of the parts involved.

Ann M. Stock, Ph.D. * - Piscataway - We study bacterial signal transduction using a combination of molecular genetic, biochemical, and X-ray crystallographic methods to study structure and function of signaling proteins. We study the role of reversible protein modification and protein-protein interactions in signaling pathways.

Ann M. Stock, Ph.D. * - Piscataway - Structure & function analysis of signal transduction proteins and the role of protein modifications such as phosphorylation and methylation. Projects include unusual mammalian protein kinases and bacterial pathogenesis. Studies employ molecular genetics, biochemistry and X-ray crystallography.

Dmitry Temiakov, Ph.D. * - Stratford - Our laboratory research is focused on studies of molecular mechanisms of transcription as carried out by different RNA polymerases. In particular, we are interested in function and structure of the human mitochondrial RNA polymerase and mechanisms of mitochondrial transcription regulation. Email: temiakdm@umdnj.edu

Donald A. Winkelmann, Ph.D. * - Piscataway - Study of macromolecular structure and assembly with our efforts concentrated on the analysis of the protein myosin and its interaction with actin.

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