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GSBS Research Topics: PROTEIN SYNTHESIS/TRANSLATION


Helen M. Berman, * - Piscataway - Our goal is to understand the structural properties of biological molecules and to relate these structures to their biological functions. Projects include the Protein Data Bank, the Nucleic Acid Database, and X-ray crystallographic and molecular modelling studies of biological molecules.

Salvatore J. Caradonna, Ph.D. * - Stratford - My laboratory is interested in the post-translational mechanisms that regulate proteins involved in base-excision repair of DNA. We are studying the aberrant pathways that lead to uracil misincorporation into DNA and strategies that may exploit these pathways for cancer drug development. We are also involved in the study of atypical cyclin-like proteins that affect cell-cycle phase transitions. Email: caradonn@umdnj.edu

Monica, A. Driscoll, Ph.D. * - Piscataway - Our lab uses the facile C. elegans model system to investigate molecular and genetic mechanisms of necrotic cell death, aging and mechanical signalling.

Emanuel Goldman, Ph.D. * - Newark - research summary: This lab studies elongation of protein synthesis in bacteria, including: 1) effects of uncharged tRNA; 2) codon bias and 5`-translational blockage; and 3) programmed translational frameshifts and other recoding events such as readthrough of stop codons.

Michael F. Henry, Ph.D. * - Stratford - We use the yeast Saccharomyces cerevisiae as a model system to understand the molecular mechanisms by which RNA precursors are processed in the nucleus. More precisely, our goal is to understand the role of posttranslational protein modification in this process. Email: henrymf@umdnj.edu

Hristo Houbaviy, Ph.D. * - Stratford - We are interested in the roles of microRNAs in embryonic stem (ES) cells and during the early development of the mouse. Specifically, we are applying biochemical and mouse model approaches to elucidate the functions of miR-290-295 / miR-371-373 which appear to be ES cell and early embryo specific. Email: houbavhr@umdnj.edu

M. Zafri Humayun, Ph.D. * - Newark - We study mechanisms of genetic variability in Escherichia coli and in the pathogen Helicobacter pylori. We have recently defined two novel transient mutator pathways termed UVM and TSM pathways. The TSM pathway reveals unanticipated links among translation, DNA replication and recombination. Antibiotics, helicase.

Masayori Inouye, Ph.D. * - Piscataway - Molecular biology of cellular adaptation to stresses (1)transmembrane signal transduction by protein histidine kinases; (2)cold-shock response and adaptation; (3)developmental signal transduction in Myxococcus xanthus; (4)GTP metabolism; (5) protein folding; (6)bacterial retroelements.

Hieronim Jakubowski, Ph.D. * - Newark - tRNA-synthetases establish the rules of the genetic code by matching amino acids with cognate tRNAs. We study: 1) accuracy of tRNA-synthetases in protein synthesis, including editing, 2)the role of homocysteine incorporation into protein(protein N-homocysteinylation) in cardiovascular disease.

Terri Goss Kinzy, Ph.D. * - Piscataway - Our lab studies the mechanism and regulation of protein synthesis and general principles of G-protein regulation. Research areas include mutational, genetic and structural analysis of translation factors and related G-proteins and their potential roles in oxidative stress and other cell processes.

Fred R. Kramer, Ph.D. * - Newark - RNA replication, RNA structure, recombinant RNA, nucleic acid probes, molecular beacons, oligonucleotide arrays

Hong Li, Ph.D. * - Newark - Center for Advanced Proteomics Research is located in MSB F602 at NJMS. This facility is equipped with state-of-the-art proteomics instruments and bioinformatics systems for protein structure and function analysis. We have a Micromass QTOF mass spectrometer and an ABI 4700 Proteomics Analyzer.

Peter Lobel, Ph.D. * - Piscataway - Our laboratory studies the role of lysosomal enzymes in normal and disease processes. Specific research interests include 1) the hereditary neurodegenerative disease late infantile neuronal ceroid lipofuscinosis; 2) identification and characterization of novel lysosomal enzymes; and 3) intracellular targeting of lysosomal enzymes.

Michael B. Mathews, Ph.D. * - Newark - Double-stranded RNA binding proteins. Highly structured RNA is an important mediator of several processes, including gene expression and anti-viral defense mechanisms. We study the biochemical properties and biological roles of proteins that function as transcriptional and translational regulators.

Eric G. Moss, Ph.D. * - Stratford - We study developmental timing, microRNAs and translational control in C. elegans and the mouse. The worm heterochronic gene lin-28 is regulated by microRNAs and encodes a specific mRNA-binding protein. Its human homologue, Lin28, appears also to be a microRNA-controlled developmental regulator. Email: mosseg@umdnj.edu

Andrew R. Pachner, M.D. * - Newark - We focus on detection of pathogen and characterization of host immune response in infections of the nervous system, particularly Lyme borreliosis. We extensively use molecular biological tools, such as PCR and microarrays.

Sidney Pestka, M.D. * - Piscataway - Research involves the cloning of interferons and their receptors, and the development of new strategies for the treatment of viral diseases and cancers. The studies involve interferon and cell surface receptors and revolve around genetic engineering, protein biochemistry, signal transduction, immunology and gene therapy.

Dimitri G. Pestov, PhD * - Stratford - We study the mechanisms of ribosome biogenesis in mammalian cells in connection with regulation of cell growth and proliferation. Our major goal is to understand how the accuracy of ribosome assembly is controlled at the molecular level and how defects in this process contribute to human disease. Email: pestovdg@umdnj.edu

Alexey, G. Ryazanov, Ph.D. * - Piscataway - We are studying the structure and function of a novel class of protein kinases that we recently discovered. These kinases are involved in the regulation of many biological processes including calcium influx, protein synthesis and aging. We are using C. elegans and mice as model systems.

Aaron Shatkin, Ph.D. * - Piscataway - Mechanisms of eukaryotic gene expression: initiation of viral and cellular transcription and translation; roles of mRNA 5`terminal cap and cap-binding proteins; protein:protein interactions linking capping to protein transport and mRNA biogenesis.

Natalia Shcherbik, Ph.D. * - Stratford - We currently focus on elucidating the mechanisms of ribosome turnover using Saccharomyces cerevisiae as a model system. We are particularly interested in the role of ubiquitination in controlling the activity of ribonucleases that target ribosomes and how this process in regulated in the cell. Email: shcherna@umdnj.edu

B.J. Wagner, Ph.D. * - Newark - Role of the ubiquitin-proteasome pathway in development, aging and response to stress: We use the mammalian ocular lens and lens cell culture models to study differentiation, cataractogenesis and oxidative stress.

* GSBS Faculty Return to Topics list


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