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Utz Herbig, Ph.D * - Newark - Our laboratory is interested in understanding how telomeres contribute cellular senescence in mammalian cells. As cellular senescence is a critical tumor suppressing mechanism, but also is thought to contribute to organismal aging, our studies are relevant for both aging- and cancer-research.

M. Zafri Humayun, Ph.D. * - Newark - We study mechanisms of genetic variability in Escherichia coli and in the pathogen Helicobacter pylori. We have recently defined two novel transient mutator pathways termed UVM and TSM pathways. The TSM pathway reveals unanticipated links among translation, DNA replication and recombination. Antibiotics, helicase.

Joseph Kedem, Ph.D. * - Piscataway - Relationship between local myocardial function and energy metabolism. Effects of various types of ischemic damage on efficiency of cardiac contraction. In vivo experiments and mathematical analyses.

Terri Goss Kinzy, Ph.D. * - Piscataway - Our lab studies the mechanism and regulation of protein synthesis and general principles of G-protein regulation. Research areas include mutational, genetic and structural analysis of translation factors and related G-proteins and their potential roles in oxidative stress and other cell processes.

S. Joseph Leibovich, Ph.D. * - Newark - Role of macrophages, nitric oxide and oxygen in regulation of angiogenesis in wound healing and cancer. Analysis of VEGF expression in macrophages and its regulation by nitric oxide. Role of ADP-ribosylation of VEGF in macrophages and its role in regulation of angiogenesis.

Dmitriy Markov, Ph.D. * - Stratford - My research is focused on regulation of mitochondrial transcription and transcription-coupled processes and how they change in response to oxidative stress in neuronal tissue. Email: markovdm@umdnj.edu

Patricia K. Sonsalla , Ph.D. * - Piscataway - Animal models of Parkinson`s disease and the mechanisms associated with the neurodegeneration and neurochemistry of dopamine neurons within the basal ganglia. We are studying the role of endogenous dopamine and oxidative products in the degeneration of these neurons under conditions of a metabolic stress.

Zoltan Spolarics, M.D., Ph.D. * - Newark - The project investigates the effects of genetic polymorphisms of metabolic enzymes and cytokines (IL-6, IL-10, IFN-γ) on the immune response. We employ genetically modified mice using experimental models of infection in vivo. We also investigate macrophage and T-cell responses in vitro. The human component of the project investigates the effects of genetic polymorphisms on the immune response in trauma patients. Infection, immunity, T-cells, macrophages, red blood cells, chemokines, polymorphism, flow cytometry, injury, host-response, malaria.

Bernd W. Spur, Ph.D. * - Stratford - We focus on mediators of inflammation, including prostaglandins, phytoprostanes, leukotrienes, lipoxins, resolvins, neuroprotectins, docosatrienes as well as isoprostanes. These mediators are prepared in the natural and isotopically labelled form to explore their biological activities and serve as markers in inflammatory diseases such as Asthma and Alzheimer. Email: spurbw@umdnj.edu

Randy Strich, Ph.D. * - Stratford - Our laboratory focuses on understanding how the transcription program is coupled to meiotic progression in budding yeast. A second project investigates the activity of the conserved C-type cyclin in directing the oxidative stress response and apoptosis in yeast and mammalian systems. Email: strichra@umdnj.edu

B.J. Wagner, Ph.D. * - Newark - Role of the ubiquitin-proteasome pathway in development, aging and response to stress: We use the mammalian ocular lens and lens cell culture models to study differentiation, cataractogenesis and oxidative stress.

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