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Kevin D. Beck, Ph.D. * - Newark - The program focuses on stress-induced changes in behavior (specifically sensory reactivity and learning/memory). Areas of interest include identifying the neural mechanisms for sex-differences in stress responding and modeling unexplained illness through associative learning of interoceptive stressors.

Bharat Biswal, Ph.D. - Newark - Medical imaging including Magnetic Resonnce Imaging (MRI) and Functional MRI, and Laser Doppler Imging. Primarily interest is in devlopment of signal/image processing techniques to better understand the signal measured and increase its application for use in basic science and clinical application.

Patrizia Casaccia-Bonnefil, M.D., Ph.D. * - Piscataway - Proliferation and differentiation of CNS precursor cells. Apoptosis mediated by death receptors in oligodendrocytes. Role of cell cycle inhibitors (p27,p21,p57) in CNS. Cancer. Multiple sclerosis. Stem Cells.

Joel A. DeLisa, M.D., M.S. * - Newark - Spinal Cord Injury - Spasticity. Regeneration, Electrodiagnostic Evaluation Systems of Clinical Care.

John DeLuca, Ph.D. * - Newark - Directs the Neuropsychology and Neuroscience Laboratory and conducts research in human memory and information processing in patients following brain damage or disease. Techniques include neuropsychological assessment and measurement, functional neuroimaging, and applying principles from cognitive neuroscience to rehabilitation following brain damage.

Monica, A. Driscoll, Ph.D. * - Piscataway - Our lab uses the facile C. elegans model system to investigate molecular and genetic mechanisms of necrotic cell death, aging and mechanical signalling.

Isaac Edery, Ph.D. * - Piscataway - We use Drosophila melanogaster as a model system to understand the molecular underpinnings governing circadian rhythms. Our main goals are to understand how a circadian oscillator is assembled and how it responds to environmental cues, most notably visible light and ambient temperature.

M. David Egger, Ph.D. * - Piscataway - Development of somatosensory system in the mammalian spinal cord and brainstem; neurogenetics in Drosophila melanogaster; models of neuronal growth

Jonathan Foulds, Ph.D. - Piscataway - Tobacco addiction, smoking cessation, health effects of tobacco, tobacco dependence treatment, psychological and behavioural effects of nicotine and nicotine withdrawal.

Jeremy Francis, Ph.D * - Stratford - Our research seeks to determine pathogenic mechanisms underlying neurodegenerative diseases in an effort to identify avenues of therapeutic intervention. Gene and cell-based therapies are used in animal models of disease to create a foundation for possible clinical application. Email: francijs@umdnj.edu

Martin Grumet, Ph.D. * - Piscataway - Cell adhesion molecules (CAMs) in neural development & nerve regeneration; Structure & function analysis for L1, Nr-CAM, and neurofascin & in formation of node of Ranvier; Nr-CAM knockout mice; gene expression in radial glia using gene chip technology; glial cell transplantation in rat spinal cord.

Andrew L. Harris, Ph.D. * - Newark - Connexins form intercellular pores through which ions and signaling molecules pass directly from cell to cell. These pores are important in signal transduction, tissue function, development and disease. Our studies explore, at the molecular level, mechanisms of selective molecular permeation, and mechanisms that regulate channel gating.

Richard D. Howells, Ph.D. * - Newark - Molecular analysis of opioid receptor structure and function. Opioid receptors are G protein-coupled receptors on the cell surface of neurons that mediate signal transduction pathways activated by endogenous opioid peptides and opiate drugs, such as morphine. Molecular consequences of opioid addiction are being investigated via gene arrays and proteomics.

Amjad A. Ilyas, Ph.D. * - Newark - We focus on the identification and characterization of autoantibodies to glycolipid and protein antigens in human demyelinating diseases, particularly the Guillain-Barre` syndrome. The role of antibodies to glycolipid antigens in the pathogenesis of neuropathy is under investigation.

Eldo, V. Kuzhikandathil, Ph.D. * - Newark - We are interested in the molecular analysis of dopamine receptor signaling mechanisms and their role in neurological diseases.Current research projects include structure-function analysis of dopamine receptors and the developmental regulation of dopamine receptor signaling pathways.

Robert W. Ledeen, Ph.D. * - Newark - 1. Ganglioside and sphingolipids in neuronal function: cell membrane and nuclear membrane. 2. Gangliosides as modulators of flux and signaling. 3. Myelin metabolism in multiple sclerosis and normal brain. Myelin receptors for cytokines. 4. N-Acetylaspartate and myelinogenesis.

Paola Leone, Ph.D * - Stratford - My research focus is to characterize neuropathological pathways underlying the degenerative processes associated with pediatric leukodystrophies, such as Canavan Disease, and test in vitro and in vivo novel pharmacological and stem cell applications for the development of a therapy for this disease and other leukodystrophies. Email: leonepa@umdnj.edu

Barry E. Levin, M.D. * - Newark - How the brain senses, integrates and regulates metabolic systems controlling energy homeostasis in obesity and in diabetes. Emphasis on diet-induced obesity, neural glucosensing, hypoglycemia-induced brain damage. Utilize behavioral, neurochemical, molecular and physiologic techniques.

Steven W Levison, Ph.D. * - Newark - The goal of Dr. Levisonís research is to enhance regeneration of the CNS from its resident stem cells and to understand the impact of neuroinflammation using cell culture and animal models of multiple sclerosis, neonatal hypoxia ischemia, traumatic brain injury and stroke.

Peter Lobel, Ph.D. * - Piscataway - Our laboratory studies the role of lysosomal enzymes in normal and disease processes. Specific research interests include 1) the hereditary neurodegenerative disease late infantile neuronal ceroid lipofuscinosis; 2) identification and characterization of novel lysosomal enzymes; and 3) intracellular targeting of lysosomal enzymes.

Paul Manowitz, Ph.D. * - Piscataway - Identification of genes predisposing to substance abuse and other human diseases of behavior. This research includes studies of tissue culture and animal models as well as humans to elucidate the genetic, molecular biological,and biochemical bases of these diseases.

Dmitriy Markov, Ph.D. * - Stratford - My research is focused on regulation of mitochondrial transcription and transcription-coupled processes and how they change in response to oxidative stress in neuronal tissue. Email: markovdm@umdnj.edu

Michael P. Matise, Ph.D. * - Piscataway - Research in the lab is directed at elucidating the molecular mechanisms controlling neurogenesis in the developing central nervous system, with an emphasis on the vertebrate (mouse, chick) spinal cord.

Joseph McArdle, Ph.D. * - Newark - Electrophysiologic techniques are used to explore the physiologic/pharmacologic properties of ligand-gated ion channels on native cells at various developmental stages as well as during pathologic conditions. Pharmacologic manipulations are used to test the importance of a receptor to the development or time course of a pathologic state.

Randall D. McKinnon, Ph.D. * - Piscataway - Oligodendrocyte development; transplantation analysis of primary OL progenitor cells engineered to be non-responsive to specific factors using dominant-negative receptor constructs; signal transduction by receptors with intrinsic catalytic protein tyrosine kinase activity; gene expression analysis using microarray chip technology.

James H. Millonig, Ph.D. * - Piscataway - The lab is interested in developmental neuroscience, using the mouse as a genetic system. The goal is to apply this research to elucidate the genetic causes of autism, a common human disease.

Stephen, J. Moorman, Ph.D. * - Piscataway - Using zebrafish as a model system, we study the development of the vestibular system and the effects of microgravity on gene expression during development.

Robert Nagele, Ph.D. * - Stratford - My laboratory is focused on elucidating the role of breakdown of the blood-brain barrier in the initiation and progression of Alzheimer`s and other neurodegenerative diseases and developing therapeutic strategies aimed at preventing this breakdown and the leak of potentially damaging blood components into the brain tissue. In addition, my laboratory is investigating the potential of certain blood-borne autoantibodies as biomarkers of disease that can be used for disease diagnostics or a monitor or disease progression. Email: nagelero@umdnj.edu

Martha C. Nowycky, Ph.D. * - Newark - We study voltage-gated calcium channels and the TRP family channels, using patch clamp, digitial imaging, and molecular biology techniques. We examine the links between neurotransmitter and hormone stimulation, signal transduction via G-proteinsand calcium stores in neurons and excitable cells.

John, E. Ottenweller, Ph.D. * - Newark - Long-term Effects of Stress on Health and Disease, Multiple Hormone Systems, Physiological Regulation and Behavior. Neuroendocrine Function in Chronic Fatigue Syndrome and Gulf War Syndrome focusing on Adrenal Axis Hormones, but including thyroid hormones and reproductive hormones.

Andrew R. Pachner, M.D. * - Newark - We focus on detection of pathogen and characterization of host immune response in infections of the nervous system, particularly Lyme borreliosis. We extensively use molecular biological tools, such as PCR and microarrays.

Nicholas M. Ponzio, Ph.D. * - Newark - Use of experimental models to study: (1) development and treatment of B cell lymphomas and leukemias, and (2) transplantation of umbilical cord blood in lieu of bone marrow for treatment of various diseases in which hematopoiesis is compromised.

Yacov Ron, Ph.D. * - Piscataway - Prevention and treatment of autoimmune encephalomyelitis (EAE) by the induction of clonal anergy to encephaltogenic determinants of myelin basic protein (MBP).

Christopher Rongo, Ph.D. * - Piscataway - We study how different neurotransmitter receptor types are sorted to the appropriate synapses in a neuron and how synapses in the central nervous system change in the growing animal. By using genetic screens, behavioral analysis, and molecular and cell biological techniques in C. elegans, we hope to identify the proteins that build and regulate synapses.

Vanessa H. Routh, Ph.D. * - Newark - Central regulation of glucose homeostasis. Electrophysiological and PCR studies of brain slices and isolated neurons in a rodent model of diet-induced obesity and type II diabetes mellitus. Focus on mechanisms by which neurons respond to physiologic changes in extracellular glucose, as well as regulation of glucosensing neurons.

Viji Santhakumar, Ph.D. * - Newark - We study the role of inhibitory circuit plasticity and innate immune response modulation in brain injury and epilepsy using electrophysiological, molecular and computational modeling approaches.

Hreday N. Sapru, Ph.D. * - Newark - Central control of cardiovascular and respiratory functions. Neural circuits and transmitters involved in different reflex mechanisms (e.g., baroreflex, chemoreflex, cardiopulmonary reflex). Alterations of these control mechanisms in pathological states (e.g., hypertension, global cerebral ischemia, adult respiratory distress syndrome).

Richard J. Servatius, Ph.D. * - Newark - Effects of environmental factors -- especially stress -- on learning and memory. Understanding adaptation through behavioral neuroscience techniques in humans and nonhuman mammals.

Roman Shirokov, Ph.D. * - Newark - Ca channels interface membrane excitability and Ca signaling. We study their inactivation, or spontaneous disabling closure. We measure ionic and gating currents, intracellular Ca signals. We use molecular engineering and bioinformatics to define the structure and interactions of the parts involved.

Allan Siegel, Ph.D. * - Newark - Our research is directed at understanding the neurobiology of feline aggression. We utilize brain stimulation, behavioral analysis, neuroanatomical and neuropharmacological methods to identify the neural circuitry and receptor-neurotransmitter properties of the neurons which mediate aggression.

Patricia K. Sonsalla , Ph.D. * - Piscataway - Animal models of Parkinson`s disease and the mechanisms associated with the neurodegeneration and neurochemistry of dopamine neurons within the basal ganglia. We are studying the role of endogenous dopamine and oxidative products in the degeneration of these neurons under conditions of a metabolic stress.

Andrew P. Thomas, Ph.D. * - Newark - 1) Calcium-dependent signal transduction in response to hormones and growth factors, and 2) the effects of cocaine and alcohol on cardiac excitation-contraction coupling. We use digital imaging and laser scanning confocal microscopy to measure calcium and monitor organelle function in living cells; ion channel electrophysiology; molecular biology.

Ellen Townes-Anderson, Ph.D. * - Newark - Using primary cultures, we are trying to understand mechanisms of regeneration, degeneration, and synaptic plasticity in photoreceptors and other types of retinal neurons. Techniques used include microscopy, optical tweezers, time lapse recording, immunocytochemistry, and molecular biology.

Venkat Venkataraman, Ph.D * - Stratford - We are investigating the processes of neuronal transduction in biological clocks and aging with respect to the role of Ca2+ signaling via alpha2 adrenergic receptors and membrane guanylate cyclases. Email: venkatar@umdnj.edu

William Wadsworth, * - Piscataway - Our laboratory is studying axon guidance and the development of the extracellular matrix. Using genetics and molecular biology techniques, we are discovering molecules that function to direct the formation of a nervous system. We use primarily the nematode C. elegans as a model organism.

Mengqing Xiang, Ph.D. * - Piscataway - Our research interests center on understanding the molecular mechanisms that govern the determination and differentiation of the highly specialized sensory neurons. We employ molecular genetic approaches in animal models to identify and study transcription factors that are required for programming development of the retina, inner ear, and somatosensory ganglia.

Jiang H. Ye, M.D. * - Newark - Patch-clamp electrophysiological techniques combined with pharmacological tests are used on neurons in brain slices and acutely isolated (enzymatically and mechanically) neurons in attempt to understand the cellular and molecular mechanisms underlying: 1) general anesthetics, and 2) alcohol addiction.

Marco Zarbin, M.D., Ph.D. * - Newark - The laboratory research focuses on the development of treatments for retinal diseases such as age-related macular degeneration through ocular cell transplantation and the stimulation of retinal pigment epithelial wound healing.

James Zheng, Ph.D. * - Piscataway - We are interested in the molecular and cellular mechanisms underlying the precise wiring of the complex nervous system. Our current work focuses on the intracellular signaling pathway that allows developing axons to detect direction from environmental cues to reach their targets for specific neuronal connections.

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