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GSBS Research Topics: MOLECULAR MODELING


Helen M. Berman, * - Piscataway - Our goal is to understand the structural properties of biological molecules and to relate these structures to their biological functions. Projects include the Protein Data Bank, the Nucleic Acid Database, and X-ray crystallographic and molecular modelling studies of biological molecules.

John, E. Kerrigan, Ph.D. * - Piscataway - Our research efforts are aimed toward the identification of novel small molecule therapetics for the treatment of cancer and other diseases using de novo computational methods. Molecular modeling of protein and dna complexes with potential drug leads is applied.

William McAllister, Ph.D * - Stratford - Molecular basis of transcription. Work in our laboratory concerns the structure and function of RNA polymerase, the enzyme that carries out the first step in gene expression, using a combination of biochemical, genetic, and structural methods. Email: mcalliwt@umdnj.edu

Mukund J. Modak, Ph.D. * - Newark - Molecular mechanism of DNA synthesis: We are investigating the mechanisms of enzymatic DNA replication. DNA polymerases from bacterial, tumor viral and mammalian sources are included in these studies. Each enzyme study also offers an opportunity to probe in vivo implication of its unique properties.

Wilma K. Olson, Ph.D. * - Piscataway - Theoretical and computational studies of the relationship of chemical architecture to the conformation, properties and interactions of biological macromolecules, with major emphasis on nucleic acids.

Sidney Pestka, M.D. * - Piscataway - Research involves the cloning of interferons and their receptors, and the development of new strategies for the treatment of viral diseases and cancers. The studies involve interferon and cell surface receptors and revolve around genetic engineering, protein biochemistry, signal transduction, immunology and gene therapy.

Narayanan Ramasubbu, Ph.D. - Newark - Structural biology of proteins that impact oral diseases and biofilms.

Roman Shirokov, Ph.D. * - Newark - Ca channels interface membrane excitability and Ca signaling. We study their inactivation, or spontaneous disabling closure. We measure ionic and gating currents, intracellular Ca signals. We use molecular engineering and bioinformatics to define the structure and interactions of the parts involved.

Dmitry Temiakov, Ph.D. * - Stratford - Our laboratory research is focused on studies of molecular mechanisms of transcription as carried out by different RNA polymerases. In particular, we are interested in function and structure of the human mitochondrial RNA polymerase and mechanisms of mitochondrial transcription regulation. Email: temiakdm@umdnj.edu

* GSBS Faculty Return to Topics list


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