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GSBS Research Topics: MITOCHONDRIAL FUNCTION


Katrina Cooper, Ph.D * - Stratford - Following stress cells have to orchestrate a myriad of responses to survive or die. Incorrect choices can lead to deleterious outcomes, e.g. tumor formation. To study this, we use S. cerevisiae, human cells and mouse models. We focus on the conserved cyclin C protein that is destroyed in response to stress and plays a role in apoptosis. Our working hypothesis is that cyclin C is a novel stress related tumor suppressor. Email: cooperka@umdnj.edu

Dmitriy Markov, Ph.D. * - Stratford - My research is focused on regulation of mitochondrial transcription and transcription-coupled processes and how they change in response to oxidative stress in neuronal tissue. Email: markovdm@umdnj.edu

William McAllister, Ph.D * - Stratford - Molecular basis of transcription. Work in our laboratory concerns the structure and function of RNA polymerase, the enzyme that carries out the first step in gene expression, using a combination of biochemical, genetic, and structural methods. Email: mcalliwt@umdnj.edu

Catherine Neary, Ph.D. * - Stratford - Hexokinase II (HK2), which catalyzes the first committed step of glycolysis, is overexpressed in many cancers. When inhibited, HK2 translocates from the mitochondria to the nucleus. I am investigating the signaling pathways that mediate HK2 mitochondrial association and nuclear translocation. Email: nearycl@umdnj.edu

* GSBS Faculty Return to Topics list


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