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Joshua R. Berlin, Ph.D. * - Newark - Voltage-dependent reaction steps in ion transport using the Na,K-ATPase as a model system. Ion transport kinetics are measured by patch-clamp in cardiac myocytes and HeLa cells expressing Na,K-ATPase enzymes containing point mutations. We also are studying Cardiac muscle excitation-contraction coupling and calcium influx.

Chavela M. Carr, Ph.D. * - Piscataway - Structural and functional studies of proteins required for regulation of intracellular membrane fusion. Saccharomyces cerevisiae is used as a model system to study the proteins that control SNARE-mediated vesicle fusion at restricted sites on the plasma membrane.

Nancy D. Connell, Ph.D. * - Newark - Using a combined approach of bacterial genetics and cell biology, we study the interaction of Mycobacterium tuberculosis with its host cell, the macrophage. We use mutants of this important pathogen to study intracellular amino acid and peptide metabolism within mouse and human macrophages. Antibiotics.

Monica, A. Driscoll, Ph.D. * - Piscataway - Our lab uses the facile C. elegans model system to investigate molecular and genetic mechanisms of necrotic cell death, aging and mechanical signalling.

David Dubnau, Ph.D. * - Newark - Research concerns regulation of competence and mechanism of DNA transport in Bacillus subtilis.

Member, Public Health Research Institute and Professor, Department of Microbiology and Molecular Genetics. Located in ICPH building, 225 Warren Street, Newark, NJ 07103.

Ronaldo P. Ferraris, * - Newark - Dietary and hormonal control of expression of intestinal nutrient transporter genes. Uses rat, mouse and fish models to study the mechanisms underlying expression of different transporters at different times of development, and the effects of nutritional status and aging on the absorption and metabolism of nutrients and on protein synthesis by intestinal cells.

Stephen Garrett, Ph.D. * - Newark - We are interested in mechanisms of cell sensing. Our studies are carried out in the yeast Saccharomyces cerevisiae and are currently directed toward elucidating the function of the second messenger cAMP, as well as understanding the mechanism of manganese homeostasis.

Gary, S. Goldberg, Ph.D. - Stratford - Cells must communicate with each other to coordinate the development and survival of an animal. This communication can be mediated by diffusible factors that pass between cells, or by direct contact through cell junctions. I am interested in how intercellular communication affects cell growth and differentiation, with an emphasis on how cell communication can control tumor cell growth and prevent eye diseases. Email: gary.goldberg@umdnj.edu

Andrew L. Harris, Ph.D. * - Newark - Connexins form intercellular pores through which ions and signaling molecules pass directly from cell to cell. These pores are important in signal transduction, tissue function, development and disease. Our studies explore, at the molecular level, mechanisms of selective molecular permeation, and mechanisms that regulate channel gating.

Eldo, V. Kuzhikandathil, Ph.D. * - Newark - We are interested in the molecular analysis of dopamine receptor signaling mechanisms and their role in neurological diseases.Current research projects include structure-function analysis of dopamine receptors and the developmental regulation of dopamine receptor signaling pathways.

Bozena B. Michniak, Ph.D. * - Newark - Research interests include topical and transdermal drug delivery, formulation optimization, design of novel drug carrier systems. P.I. has developed a novel bioengineered full thickness skin construct for use as a model for membrane transport.

John P. Reeves, Ph.D. * - Newark - The Na/Ca exchange system is the principal Ca efflux mechanism in cardiac muscle cells and plays an important role in regulating cardiac contractility. We study the cellular mechanisms that control the activity of this important transporter using molecular and Ca imaging techniques.

Roman Shirokov, Ph.D. * - Newark - Ca channels interface membrane excitability and Ca signaling. We study their inactivation, or spontaneous disabling closure. We measure ionic and gating currents, intracellular Ca signals. We use molecular engineering and bioinformatics to define the structure and interactions of the parts involved.

Andrew P. Thomas, Ph.D. * - Newark - 1) Calcium-dependent signal transduction in response to hormones and growth factors, and 2) the effects of cocaine and alcohol on cardiac excitation-contraction coupling. We use digital imaging and laser scanning confocal microscopy to measure calcium and monitor organelle function in living cells; ion channel electrophysiology; molecular biology.

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