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GSBS Research Topics: INFLAMMATION


Scott R. Diehl, Ph.D. * - Newark - Single Nucleotide Polymorphisms (SNPs) are analyzed to understand molecular causes of disease and individual differences in drug responses. High-throughput bioinformatics and complex statistical genetic methods are used for current research on oral cancer, periodontal disease, orofacial clefting; pharmacogenomics of pain and drug responses.

Walter N. Duran, Ph.D. * - Newark - Signaling between the vascular wall and blood cells: 1) role of NOS in hyperpermeability induced by inflammatory agents; 2) signaling pathways in the control of permeability 3) permeability alterations associated with microvascular dysfunction. We use intravital microscopy, computer-assisted image analysis, Western blotting, and reverse transcriptase PCR.

Grant Gallagher, Ph.D. * - Stratford - Key interests revolve around the regulation of Th2 responses in conditions such as asthma and the regulation of Th17 responses in conditions such as inflammatory bowel disease and prostate cancer. There are developing interests in systemic lupus erythematosus and first-trimester miscarriage also. The work is directed towards the development of novel diagnostic and therapeutic approaches to such conditions. Disease models are used, but primarily the research uses human cells from both healthy individuals and patients. Email: g.gallagher@humigen.org

Carl J. Hauser, M.D. - Newark - My laboratory studies neutrophil functional responses in the inflammatory cytokine milieu generated by trauma. We have a special interest in the cross regulation of G-protein coupled receptors and the mechanisms of their mobilization of cell calcium under such conditions.

Carl Hock, Ph.D. * - Stratford - Current work is focused on the effect of humoral mediators and inflammatory cells in the pathophysiology of ischemic states, the effects of dietary lipids on cardiovascular function and the response of the young and aging heart to ischemia and reperfusion. Email: hock@umdnj.edu

S. Joseph Leibovich, Ph.D. * - Newark - Role of macrophages, nitric oxide and oxygen in regulation of angiogenesis in wound healing and cancer. Analysis of VEGF expression in macrophages and its regulation by nitric oxide. Role of ADP-ribosylation of VEGF in macrophages and its role in regulation of angiogenesis.

Steven W Levison, Ph.D. * - Newark - The goal of Dr. Levisonís research is to enhance regeneration of the CNS from its resident stem cells and to understand the impact of neuroinflammation using cell culture and animal models of multiple sclerosis, neonatal hypoxia ischemia, traumatic brain injury and stroke.

Peitan Liu, M.D/Ph.D. * - Stratford - Work in the laboratory concerns the role of cytokines and reactive oxygen species in ischemia-reperfusion injury. Currently we focus on the study of myocyte apoptosis, particularly the role of Mdm2/p53-mediated apoptosis, in aged rat model of myocardial ischemia-reperfusion. Email: liupe@umdnj.edu

David M. Lukac, Ph.D. * - Newark - Molecular virology of Kaposi`s sarcoma-associated herpesvirus (HHV-8) in the pathogenesis of Kaposi`s sarcoma and primary effusion lymphoma.

Nicholas Megjugorac, Ph.D. * - Stratford - My work is currently focused on three aspects of the IL-17 axis of inflammation. (I) Defining the role of IFN-lambda on Th17 differentiation and cytokine expression. (II) Characterizing differences in IL-17 signaling in normal and malignant prostate cells. (III) Identifying mRNA expression profiles in the whole blood of patients with Inflammatory Bowel Disease. Email: N.Megjugorac@Humigen.org

Robert Nagele, Ph.D. * - Stratford - My laboratory is focused on elucidating the role of breakdown of the blood-brain barrier in the initiation and progression of Alzheimer`s and other neurodegenerative diseases and developing therapeutic strategies aimed at preventing this breakdown and the leak of potentially damaging blood components into the brain tissue. In addition, my laboratory is investigating the potential of certain blood-borne autoantibodies as biomarkers of disease that can be used for disease diagnostics or a monitor or disease progression. Email: nagelero@umdnj.edu

Andrew R. Pachner, M.D. * - Newark - We focus on detection of pathogen and characterization of host immune response in infections of the nervous system, particularly Lyme borreliosis. We extensively use molecular biological tools, such as PCR and microarrays.

Christine M. Rohowsky-Kochan, Ph.D. * - Newark - Studies focus on the nature and regulation of autoreactive T cells in multiple sclerosis and on the viral etiology of multiple sclerosis. Emphasis is on the role of cytokines and their control. Utilize immunological and molecular techniques.

Viji Santhakumar, Ph.D. * - Newark - We study the role of inhibitory circuit plasticity and innate immune response modulation in brain injury and epilepsy using electrophysiological, molecular and computational modeling approaches.

Bernd W. Spur, Ph.D. * - Stratford - We focus on mediators of inflammation, including prostaglandins, phytoprostanes, leukotrienes, lipoxins, resolvins, neuroprotectins, docosatrienes as well as isoprostanes. These mediators are prepared in the natural and isotopically labelled form to explore their biological activities and serve as markers in inflammatory diseases such as Asthma and Alzheimer. Email: spurbw@umdnj.edu

Ilana Stroke, Ph.D. * - Stratford - We are using high throughput compound screening (HTS) technology to identify small molecules providing the basis for novel drugs modulating microbial infection, cancer, inflammation, metabolic disease, and cardiovascular disease. Email: istroke@venenumbiodesign.com

Kingsley Yin, Ph.D. * - Stratford - Research focuses on cytokines and other inflammatory mediators in sepsis. The role of Lipoxin A4 in macrophage function, resolving inflammation and mortality during sepsis is being investigated. The effects of Lipoxin A4 on the activity of the transcription factor -NF-kB, is also being established in sepsis. Email: yinki@umdnj.edu

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