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GSBS Research Topics: HIV/AIDS

Scott R. Diehl, Ph.D. * - Newark - Single Nucleotide Polymorphisms (SNPs) are analyzed to understand molecular causes of disease and individual differences in drug responses. High-throughput bioinformatics and complex statistical genetic methods are used for current research on oral cancer, periodontal disease, orofacial clefting; pharmacogenomics of pain and drug responses.

Joseph P. Dougherty, Ph.D. * - Piscataway - Retroviral replication and the design and use of retroviral vectors for somatic cell gene therapy, studies of retroviral mutation using retroviral vectors and packaging cells, and murine model for somatic cell gene therapy.

Patricia Fitzgerald-Bocarsly, Ph.D. * - Newark - Studies on the inate immune response to viral infection are focused on a dendritic cell subpopulation (DC2) that produces interferon-alpha in response to viral stimulation. Mechanisms of viral induction of IFN in these cells and their interactions with natural killer cells, and T helper cells are under investigation.

Abram Gabriel, M.D. * - Piscataway - My laboratory focuses on the study of mechanisms and consequences of retrotransposon reverse transcription.

Fred R. Kramer, Ph.D. * - Newark - RNA replication, RNA structure, recombinant RNA, nucleic acid probes, molecular beacons, oligonucleotide arrays

Michael J. Leibowitz, Ph.D. * - Piscataway - Study of therapeutic agents acting on RNA targets to inhibit Tat-mediated transactivation in HIV-1 and group I intron ribozymes of fungi; epigenetic regulation of viral gene expression; polymeric drug delivery systems. Antibiotics.

David M. Lukac, Ph.D. * - Newark - Molecular virology of Kaposi`s sarcoma-associated herpesvirus (HHV-8) in the pathogenesis of Kaposi`s sarcoma and primary effusion lymphoma.

Michael B. Mathews, Ph.D. * - Newark - The regulation of HIV transcription. We are studying how the essential HIV Tat protein activates transcription and regulates the course of viral infection by interacting with cellular proteins, most notably a transcription elongation factor called P-TEFb or CDK9/cyclin T.

Mukund J. Modak, Ph.D. * - Newark - Molecular mechanism of DNA synthesis: We are investigating the mechanisms of enzymatic DNA replication. DNA polymerases from bacterial, tumor viral and mammalian sources are included in these studies. Each enzyme study also offers an opportunity to probe in vivo implication of its unique properties.

Virendra N. Pandey, Ph.D. * - Newark - (1) Structure-Function relationship in HIV-1 Reverse transcriptase: Role of the p51 subunit of HIV-1 reverse transcriptase in the process of reverse transcription is being investigated (2) Development of genome targeted inhibitors of retroviruses is under investigation.

Arnold B. Rabson, M.D. * - Piscataway - Our laboratory studies the molecular virology of HIV/AIDS and HTLV with a focus on regulation of viral gene expression. A second focus is the role of transcription factors in cancer and oncogenesis, particularly in lymphomas and prostate cancer.

* GSBS Faculty Return to Topics list

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