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GSBS Research Topics: ELECTROPHYSIOLOGY


Joshua R. Berlin, Ph.D. * - Newark - Voltage-dependent reaction steps in ion transport using the Na,K-ATPase as a model system. Ion transport kinetics are measured by patch-clamp in cardiac myocytes and HeLa cells expressing Na,K-ATPase enzymes containing point mutations. We also are studying Cardiac muscle excitation-contraction coupling and calcium influx.

M. David Egger, Ph.D. * - Piscataway - Development of somatosensory system in the mammalian spinal cord and brainstem; neurogenetics in Drosophila melanogaster; models of neuronal growth

Gary, S. Goldberg, Ph.D. - Stratford - Cells must communicate with each other to coordinate the development and survival of an animal. This communication can be mediated by diffusible factors that pass between cells, or by direct contact through cell junctions. I am interested in how intercellular communication affects cell growth and differentiation, with an emphasis on how cell communication can control tumor cell growth and prevent eye diseases. Email: gary.goldberg@umdnj.edu

Andrew L. Harris, Ph.D. * - Newark - Connexins form intercellular pores through which ions and signaling molecules pass directly from cell to cell. These pores are important in signal transduction, tissue function, development and disease. Our studies explore, at the molecular level, mechanisms of selective molecular permeation, and mechanisms that regulate channel gating.

Eldo, V. Kuzhikandathil, Ph.D. * - Newark - We are interested in the molecular analysis of dopamine receptor signaling mechanisms and their role in neurological diseases.Current research projects include structure-function analysis of dopamine receptors and the developmental regulation of dopamine receptor signaling pathways.

Joseph Martin, Ph.D. * - Stratford - We study how thyroid hormones (TH) influence the adult mammalian brain through nongenomic mechanisms. THs modulate GABAa receptor binding and protein phosphorylation in nerve terminal fractions without cell nuclei. Currently, temporal patterns of TH release from brain tissue are measured in relation to the subsequent cellular TH response and EEG. Email: jomartin@camden.rutgers.edu

Joseph McArdle, Ph.D. * - Newark - Electrophysiologic techniques are used to explore the physiologic/pharmacologic properties of ligand-gated ion channels on native cells at various developmental stages as well as during pathologic conditions. Pharmacologic manipulations are used to test the importance of a receptor to the development or time course of a pathologic state.

Vanessa H. Routh, Ph.D. * - Newark - Central regulation of glucose homeostasis. Electrophysiological and PCR studies of brain slices and isolated neurons in a rodent model of diet-induced obesity and type II diabetes mellitus. Focus on mechanisms by which neurons respond to physiologic changes in extracellular glucose, as well as regulation of glucosensing neurons.

Viji Santhakumar, Ph.D. * - Newark - We study the role of inhibitory circuit plasticity and innate immune response modulation in brain injury and epilepsy using electrophysiological, molecular and computational modeling approaches.

Hreday N. Sapru, Ph.D. * - Newark - Central control of cardiovascular and respiratory functions. Neural circuits and transmitters involved in different reflex mechanisms (e.g., baroreflex, chemoreflex, cardiopulmonary reflex). Alterations of these control mechanisms in pathological states (e.g., hypertension, global cerebral ischemia, adult respiratory distress syndrome).

Roman Shirokov, Ph.D. * - Newark - Ca channels interface membrane excitability and Ca signaling. We study their inactivation, or spontaneous disabling closure. We measure ionic and gating currents, intracellular Ca signals. We use molecular engineering and bioinformatics to define the structure and interactions of the parts involved.

Allan Siegel, Ph.D. * - Newark - Our research is directed at understanding the neurobiology of feline aggression. We utilize brain stimulation, behavioral analysis, neuroanatomical and neuropharmacological methods to identify the neural circuitry and receptor-neurotransmitter properties of the neurons which mediate aggression.

Andrew P. Thomas, Ph.D. * - Newark - 1) Calcium-dependent signal transduction in response to hormones and growth factors, and 2) the effects of cocaine and alcohol on cardiac excitation-contraction coupling. We use digital imaging and laser scanning confocal microscopy to measure calcium and monitor organelle function in living cells; ion channel electrophysiology; molecular biology.

Jiang H. Ye, M.D. * - Newark - Patch-clamp electrophysiological techniques combined with pharmacological tests are used on neurons in brain slices and acutely isolated (enzymatically and mechanically) neurons in attempt to understand the cellular and molecular mechanisms underlying: 1) general anesthetics, and 2) alcohol addiction.

* GSBS Faculty Return to Topics list


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