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Vivian Bellofatto, Ph.D. * - Newark - Our laboratory is investigating the transcriptional mechanisms that trypanosomes use to direct and modulate gene expression. Trypanosomes are parasitic protozoa which cause a multitude of diseases around the world. We have identified novel transcription factors in these parasites.

Barbara M. Brodsky, Ph.D. * - Piscataway - Biophysical studies on peptides which model the collagen triple-helix in various collagen types as well as in C1q, collectins, and the macrophage scavenger receptor. The effects of mutations found in genetic diseases are characterized.

Patrizia Casaccia-Bonnefil, M.D., Ph.D. * - Piscataway - Proliferation and differentiation of CNS precursor cells. Apoptosis mediated by death receptors in oligodendrocytes. Role of cell cycle inhibitors (p27,p21,p57) in CNS. Cancer. Multiple sclerosis. Stem Cells.

Kiran Chada, Ph.D. * - Piscataway - Mammalian genetics developmental biology, functional genomics, transgenic mice, human diseases, cancer and obesity.

Kiron M. Das, M.D., Ph.D. * - Piscataway - A spectra of gastrointestinal disorders treated with state-of-the-art equipment and interdisciplinary approach. Various programs include: Esophagus, Stomach and Colon Cancer Prevention,Pancreas and Biliary Tract,Swallowing Disorders, Gastroesophageal Reflux Disorder, Peptic Ulcer and Liver Disease.

Scott R. Diehl, Ph.D. * - Newark - Single Nucleotide Polymorphisms (SNPs) are analyzed to understand molecular causes of disease and individual differences in drug responses. High-throughput bioinformatics and complex statistical genetic methods are used for current research on oral cancer, periodontal disease, orofacial clefting; pharmacogenomics of pain and drug responses.

Patricia Fitzgerald-Bocarsly, Ph.D. * - Newark - Studies on the inate immune response to viral infection are focused on a dendritic cell subpopulation (DC2) that produces interferon-alpha in response to viral stimulation. Mechanisms of viral induction of IFN in these cells and their interactions with natural killer cells, and T helper cells are under investigation.

Grant Gallagher, Ph.D. * - Stratford - Key interests revolve around the regulation of Th2 responses in conditions such as asthma and the regulation of Th17 responses in conditions such as inflammatory bowel disease and prostate cancer. There are developing interests in systemic lupus erythematosus and first-trimester miscarriage also. The work is directed towards the development of novel diagnostic and therapeutic approaches to such conditions. Disease models are used, but primarily the research uses human cells from both healthy individuals and patients. Email: g.gallagher@humigen.org

Gary, S. Goldberg, Ph.D. - Stratford - Cells must communicate with each other to coordinate the development and survival of an animal. This communication can be mediated by diffusible factors that pass between cells, or by direct contact through cell junctions. I am interested in how intercellular communication affects cell growth and differentiation, with an emphasis on how cell communication can control tumor cell growth and prevent eye diseases. Email: gary.goldberg@umdnj.edu

Amjad A. Ilyas, Ph.D. * - Newark - We focus on the identification and characterization of autoantibodies to glycolipid and protein antigens in human demyelinating diseases, particularly the Guillain-Barre` syndrome. The role of antibodies to glycolipid antigens in the pathogenesis of neuropathy is under investigation.

Hieronim Jakubowski, Ph.D. * - Newark - tRNA-synthetases establish the rules of the genetic code by matching amino acids with cognate tRNAs. We study: 1) accuracy of tRNA-synthetases in protein synthesis, including editing, 2)the role of homocysteine incorporation into protein(protein N-homocysteinylation) in cardiovascular disease.

Joseph Kedem, Ph.D. * - Piscataway - Relationship between local myocardial function and energy metabolism. Effects of various types of ischemic damage on efficiency of cardiac contraction. In vivo experiments and mathematical analyses.

Eldo, V. Kuzhikandathil, Ph.D. * - Newark - We are interested in the molecular analysis of dopamine receptor signaling mechanisms and their role in neurological diseases.Current research projects include structure-function analysis of dopamine receptors and the developmental regulation of dopamine receptor signaling pathways.

Robert W. Ledeen, Ph.D. * - Newark - 1. Ganglioside and sphingolipids in neuronal function: cell membrane and nuclear membrane. 2. Gangliosides as modulators of flux and signaling. 3. Myelin metabolism in multiple sclerosis and normal brain. Myelin receptors for cytokines. 4. N-Acetylaspartate and myelinogenesis.

Peter Lobel, Ph.D. * - Piscataway - Our laboratory studies the role of lysosomal enzymes in normal and disease processes. Specific research interests include 1) the hereditary neurodegenerative disease late infantile neuronal ceroid lipofuscinosis; 2) identification and characterization of novel lysosomal enzymes; and 3) intracellular targeting of lysosomal enzymes.

Carol S. Lutz, Ph.D. * - Newark - We are interested in how eukaryotic gene expression is regulated at the level of mRNA processing, particularly in splicing and polyadenylation. Some of the protein factors involved are autoantigens in patients with lupus, and we are also interested in understanding this phenomenon.

Paul Manowitz, Ph.D. * - Piscataway - Identification of genes predisposing to substance abuse and other human diseases of behavior. This research includes studies of tissue culture and animal models as well as humans to elucidate the genetic, molecular biological,and biochemical bases of these diseases.

Michael B. Mathews, Ph.D. * - Newark - The regulation of HIV transcription. We are studying how the essential HIV Tat protein activates transcription and regulates the course of viral infection by interacting with cellular proteins, most notably a transcription elongation factor called P-TEFb or CDK9/cyclin T.

Joseph McArdle, Ph.D. * - Newark - Electrophysiologic techniques are used to explore the physiologic/pharmacologic properties of ligand-gated ion channels on native cells at various developmental stages as well as during pathologic conditions. Pharmacologic manipulations are used to test the importance of a receptor to the development or time course of a pathologic state.

Randall D. McKinnon, Ph.D. * - Piscataway - Oligodendrocyte development; transplantation analysis of primary OL progenitor cells engineered to be non-responsive to specific factors using dominant-negative receptor constructs; signal transduction by receptors with intrinsic catalytic protein tyrosine kinase activity; gene expression analysis using microarray chip technology.

James H. Millonig, Ph.D. * - Piscataway - The lab is interested in developmental neuroscience, using the mouse as a genetic system. The goal is to apply this research to elucidate the genetic causes of autism, a common human disease.

Robert Nagele, Ph.D. * - Stratford - My laboratory is focused on elucidating the role of breakdown of the blood-brain barrier in the initiation and progression of Alzheimer`s and other neurodegenerative diseases and developing therapeutic strategies aimed at preventing this breakdown and the leak of potentially damaging blood components into the brain tissue. In addition, my laboratory is investigating the potential of certain blood-borne autoantibodies as biomarkers of disease that can be used for disease diagnostics or a monitor or disease progression. Email: nagelero@umdnj.edu

Andrew R. Pachner, M.D. * - Newark - We focus on detection of pathogen and characterization of host immune response in infections of the nervous system, particularly Lyme borreliosis. We extensively use molecular biological tools, such as PCR and microarrays.

Nikhat Parveen, Ph.D * - Newark - My laboratory is studying the molecular basis of pathogenesis of two bacterial species, Borrelia burgdorferi and Pseudomonas aeruginosa. These two clinically important bacterial pathogens are transmitted to humans using different mechanisms and also show different disease manifestations. B. burgdorferi is transmitted by Ixodes tick vector while P. aeruginosa is transmitted through a variety of contaminated sources.

Narayanan Ramasubbu, Ph.D. - Newark - Structural biology of proteins that impact oral diseases and biofilms.

Christine M. Rohowsky-Kochan, Ph.D. * - Newark - Studies focus on the nature and regulation of autoreactive T cells in multiple sclerosis and on the viral etiology of multiple sclerosis. Emphasis is on the role of cytokines and their control. Utilize immunological and molecular techniques.

Vanessa H. Routh, Ph.D. * - Newark - Central regulation of glucose homeostasis. Electrophysiological and PCR studies of brain slices and isolated neurons in a rodent model of diet-induced obesity and type II diabetes mellitus. Focus on mechanisms by which neurons respond to physiologic changes in extracellular glucose, as well as regulation of glucosensing neurons.

Amrik Sahota, Ph.D. * - Piscataway - (1) molecular genetics of adenine phosphoribosyltransferase (APRT) deficiency, a disorder that often leads to kidney stone disease; (2) molecular pathophysiology of stone disease in a knockout mouse model for APRT deficiency; (3) microchimerism in transplant tolerance following organ transplantation; and (4) genetics and epidemiology of late-onset Alzheimer disease.

Viji Santhakumar, Ph.D. * - Newark - We study the role of inhibitory circuit plasticity and innate immune response modulation in brain injury and epilepsy using electrophysiological, molecular and computational modeling approaches.

B.J. Wagner, Ph.D. * - Newark - Role of the ubiquitin-proteasome pathway in development, aging and response to stress: We use the mammalian ocular lens and lens cell culture models to study differentiation, cataractogenesis and oxidative stress.

Yuh-Hwa Wang, Ph.D. * - Piscataway - Expanded triplet repeats in human genetic diseases; the nature of human chromosomal fragile sites.

Nancy, A. Woychik, Ph.D. * - Piscataway - RNA polymerases and transcription regulation in cancer and other diseases; Alterations in host cell transcription upon smallpox virus infection; Transcription mechanisms important for Chlamydia pathogenesis; Chlamydia infection and heart disease.

Lizhao Wu, Ph.D. * - Newark - We use a combination of molecular, cellular, and genetic approaches to identify key molecules that are important for cancer. Both cell culture systems and mouse models are used to delineate various tumor suppressor/oncogenic pathways in the hematopoietic system, prostate gland, and mammary gland.

Hua Zhu, Ph.D. * - Newark - My lab is studying cytomegalovirus, including host responses to viral infection, i.e. changes of signal transduction, and to understand how these responses influence viral replication and pathogenesis, and use microarray and mass spectrometry technologies to study viral and cellular gene expression.

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