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GSBS Research Topics: DEVELOPMENT


Patrizia Casaccia-Bonnefil, M.D., Ph.D. * - Piscataway - Proliferation and differentiation of CNS precursor cells. Apoptosis mediated by death receptors in oligodendrocytes. Role of cell cycle inhibitors (p27,p21,p57) in CNS. Cancer. Multiple sclerosis. Stem Cells.

Xuemei Chen, * - Piscataway - We are interested in cell fate specification in Arabidopsis flower development. Molecular genetic approaches are being taken to identify and study floral homeotic genes that direct the developmental programs leading to stamen and carpel identities.

Monica, A. Driscoll, Ph.D. * - Piscataway - Our lab uses the facile C. elegans model system to investigate molecular and genetic mechanisms of necrotic cell death, aging and mechanical signalling.

M. David Egger, Ph.D. * - Piscataway - Development of somatosensory system in the mammalian spinal cord and brainstem; neurogenetics in Drosophila melanogaster; models of neuronal growth

Ronald Ellis, Ph.D. * - Stratford - Control of Germ Cell Fate: Animals must produce sperm or eggs to reproduce. Although these cell types differ dramatically, they are produced from similar progenitors. Understanding how this process is controlled could revolutionize our ability to treat reproductive disorders and infertility in humans. Evolution of Hermaphroditism: Sexual traits are among the most rapidly changing features of each species. To learn how these changes take place, and how developmental pathways constrain which ones occur, we are studying the evolution of mating systems in nematodes. Email: ellisre@umdnj.edu

Ronaldo P. Ferraris, * - Newark - Dietary and hormonal control of expression of intestinal nutrient transporter genes. Uses rat, mouse and fish models to study the mechanisms underlying expression of different transporters at different times of development, and the effects of nutritional status and aging on the absorption and metabolism of nutrients and on protein synthesis by intestinal cells.

Jeremy Francis, Ph.D * - Stratford - Our research seeks to determine pathogenic mechanisms underlying neurodegenerative diseases in an effort to identify avenues of therapeutic intervention. Gene and cell-based therapies are used in animal models of disease to create a foundation for possible clinical application. Email: francijs@umdnj.edu

Martin Grumet, Ph.D. * - Piscataway - Cell adhesion molecules (CAMs) in neural development & nerve regeneration; Structure & function analysis for L1, Nr-CAM, and neurofascin & in formation of node of Ranvier; Nr-CAM knockout mice; gene expression in radial glia using gene chip technology; glial cell transplantation in rat spinal cord.

Hristo Houbaviy, Ph.D. * - Stratford - We are interested in the roles of microRNAs in embryonic stem (ES) cells and during the early development of the mouse. Specifically, we are applying biochemical and mouse model approaches to elucidate the functions of miR-290-295 / miR-371-373 which appear to be ES cell and early embryo specific. Email: houbavhr@umdnj.edu

Kathryn Iacono, Ph.D. * - Stratford - The primary focus of our group is the development and validation of assays traditionally focused on the area of infectious disease. Our proposed research project will help elucidate the mechanism of bacterial vaginosis by focusing on the interplay among lactobacillus strains that result in fluctuations of vaginal pH. Clinically diagnosed patient specimen will be used to correlate our findings. Email: kiacono@mdlab.com

Ken Irvine, * - Piscataway - The primary focus of our research is the regulation of patterning and growth during animal development, with a particular emphasis on Notch signaling. Our work takes advantage of the powerful genetic, molecular and cellular techniques available in Drosophila, which facilitate both gene discovery and the analysis of gene function.

Eldo, V. Kuzhikandathil, Ph.D. * - Newark - We are interested in the molecular analysis of dopamine receptor signaling mechanisms and their role in neurological diseases.Current research projects include structure-function analysis of dopamine receptors and the developmental regulation of dopamine receptor signaling pathways.

Michael Law, Ph.D. * - Stratford - Using S. cerevisiae as a model system, my work is aimed at determining how cell fate decisions are established. Differentiation requires temporal restrictions on transcription to be maintained. My work is interested in defining how post-translational protein modifications allow epigenetic regulation of transcriptional timing. Email: lawmj@umdnj.edu

Deborah, A. Lazzarino, Ph.D. * - Newark - Research studies in stem cell biology of the mammary gland in both normal and oncogenic development.

Paola Leone, Ph.D * - Stratford - My research focus is to characterize neuropathological pathways underlying the degenerative processes associated with pediatric leukodystrophies, such as Canavan Disease, and test in vitro and in vivo novel pharmacological and stem cell applications for the development of a therapy for this disease and other leukodystrophies. Email: leonepa@umdnj.edu

Barry E. Levin, M.D. * - Newark - How the brain senses, integrates and regulates metabolic systems controlling energy homeostasis in obesity and in diabetes. Emphasis on diet-induced obesity, neural glucosensing, hypoglycemia-induced brain damage. Utilize behavioral, neurochemical, molecular and physiologic techniques.

Steven W Levison, Ph.D. * - Newark - The goal of Dr. Levisonís research is to enhance regeneration of the CNS from its resident stem cells and to understand the impact of neuroinflammation using cell culture and animal models of multiple sclerosis, neonatal hypoxia ischemia, traumatic brain injury and stroke.

Michael P. Matise, Ph.D. * - Piscataway - Research in the lab is directed at elucidating the molecular mechanisms controlling neurogenesis in the developing central nervous system, with an emphasis on the vertebrate (mouse, chick) spinal cord.

Joseph McArdle, Ph.D. * - Newark - Electrophysiologic techniques are used to explore the physiologic/pharmacologic properties of ligand-gated ion channels on native cells at various developmental stages as well as during pathologic conditions. Pharmacologic manipulations are used to test the importance of a receptor to the development or time course of a pathologic state.

Kim S. McKim, Ph.D. * - Piscataway - My laboratory is characterizing genes with important roles in either meiotic recombination or segregation of chromosomes using Drosophila melanogaster as a model system. Many of these genes are also involved in DNA repair and we are characterizing their functions during Drosophila development.

James H. Millonig, Ph.D. * - Piscataway - The lab is interested in developmental neuroscience, using the mouse as a genetic system. The goal is to apply this research to elucidate the genetic causes of autism, a common human disease.

Stephen, J. Moorman, Ph.D. * - Piscataway - Using zebrafish as a model system, we study the development of the vestibular system and the effects of microgravity on gene expression during development.

Eric G. Moss, Ph.D. * - Stratford - We study developmental timing, microRNAs and translational control in C. elegans and the mouse. The worm heterochronic gene lin-28 is regulated by microRNAs and encodes a specific mRNA-binding protein. Its human homologue, Lin28, appears also to be a microRNA-controlled developmental regulator. Email: mosseg@umdnj.edu

Richard W. Padgett, Ph.D. * - Piscataway - Transforming growth factor-beta (TGFb) signal transduction, especially identification of new signaling components of the pathway and the developmental outputs from TGFb signals. We use biochemical, genetic and developmental tools to study this pathway in model systems of C. elegans and Drosophila.

Garth I. Patterson, Ph.D. * - Piscataway - We study a TGF-beta pathway that controls C. elegans larval development. We wish to learn how this pathway controls a neuroendocrine signal, as well as how this signal is transduced.

Melissa B. Rogers, Ph.D. * - Newark - Retinoids control cell cycle, apoptosis, & differentiation. We study how retinoic acid controls key genes like BMP-2. We use enhancer traps to isolate RA response elements. Our functional genomics approach should identify RA-regulated genes that initiate critical signaling cascades in development.

Christopher Rongo, Ph.D. * - Piscataway - We study how different neurotransmitter receptor types are sorted to the appropriate synapses in a neuron and how synapses in the central nervous system change in the growing animal. By using genetic screens, behavioral analysis, and molecular and cell biological techniques in C. elegans, we hope to identify the proteins that build and regulate synapses.

Andrew Singson, Ph.D. - Piscataway - The goal of research in the lab is to understand the molecular events that mediate sperm-egg interactions. The genetic and molecular dissection of these events will also provide insights relevant to other important cell-cell interactions in multicellular organisms.

William Wadsworth, * - Piscataway - Our laboratory is studying axon guidance and the development of the extracellular matrix. Using genetics and molecular biology techniques, we are discovering molecules that function to direct the formation of a nervous system. We use primarily the nematode C. elegans as a model organism.

B.J. Wagner, Ph.D. * - Newark - Role of the ubiquitin-proteasome pathway in development, aging and response to stress: We use the mammalian ocular lens and lens cell culture models to study differentiation, cataractogenesis and oxidative stress.

Lizhao Wu, Ph.D. * - Newark - We use a combination of molecular, cellular, and genetic approaches to identify key molecules that are important for cancer. Both cell culture systems and mouse models are used to delineate various tumor suppressor/oncogenic pathways in the hematopoietic system, prostate gland, and mammary gland.

Jiang H. Ye, M.D. * - Newark - Patch-clamp electrophysiological techniques combined with pharmacological tests are used on neurons in brain slices and acutely isolated (enzymatically and mechanically) neurons in attempt to understand the cellular and molecular mechanisms underlying: 1) general anesthetics, and 2) alcohol addiction.

Peter D. Yurchenco, M.D., Ph.D. * - Piscataway - Basement membranes are extracellular matrices that contribute to multiple steps of development and the maintenance of tissue function. Our current focus is on the molecular mechanisms underlying laminin-cell interactions and the relationship between laminin matrix-assembly and receptor activation.

* GSBS Faculty Return to Topics list


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