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GSBS Research Topics: CYTOKINES

Beverly E. Barton, Ph.D. - Newark - We are studying the role of IL-6-like cytokines and signal transduction in prostate cancer. Using approaches from immunology, e.g. flow cytometry to measure activated signaling proteins, we have demonstrated the activation of STAT3 in neoplastic but not hyperplastic prostate cells.

Frederick D. Coffman, Ph.D. * - Newark - Proteins and DNA sequences which regulate the initiation of DNA replication at human replication origins. We also examine the mechanism of tumor necrosis factor cytotoxicity and modulation of TNF sensitivity by antitumor drugs.

Nancy D. Connell, Ph.D. * - Newark - Using a combined approach of bacterial genetics and cell biology, we study the interaction of Mycobacterium tuberculosis with its host cell, the macrophage. We use mutants of this important pathogen to study intracellular amino acid and peptide metabolism within mouse and human macrophages. Antibiotics.

Walter N. Duran, Ph.D. * - Newark - Signaling between the vascular wall and blood cells: 1) role of NOS in hyperpermeability induced by inflammatory agents; 2) signaling pathways in the control of permeability 3) permeability alterations associated with microvascular dysfunction. We use intravital microscopy, computer-assisted image analysis, Western blotting, and reverse transcriptase PCR.

Patricia Fitzgerald-Bocarsly, Ph.D. * - Newark - Studies on the inate immune response to viral infection are focused on a dendritic cell subpopulation (DC2) that produces interferon-alpha in response to viral stimulation. Mechanisms of viral induction of IFN in these cells and their interactions with natural killer cells, and T helper cells are under investigation.

Grant Gallagher, Ph.D. * - Stratford - Key interests revolve around the regulation of Th2 responses in conditions such as asthma and the regulation of Th17 responses in conditions such as inflammatory bowel disease and prostate cancer. There are developing interests in systemic lupus erythematosus and first-trimester miscarriage also. The work is directed towards the development of novel diagnostic and therapeutic approaches to such conditions. Disease models are used, but primarily the research uses human cells from both healthy individuals and patients. Email: g.gallagher@humigen.org

Carl J. Hauser, M.D. - Newark - My laboratory studies neutrophil functional responses in the inflammatory cytokine milieu generated by trauma. We have a special interest in the cross regulation of G-protein coupled receptors and the mechanisms of their mobilization of cell calcium under such conditions.

Jerome A. Langer, Ph.D. * - Piscataway - Our interests include how diverse Type I interferons are differentially recognized by a common cell surface receptor and sometimes initiate different cellular responses. We are also examining cellular responses to flaviviruses, particularly dengue virus.

Robert W. Ledeen, Ph.D. * - Newark - 1. Ganglioside and sphingolipids in neuronal function: cell membrane and nuclear membrane. 2. Gangliosides as modulators of flux and signaling. 3. Myelin metabolism in multiple sclerosis and normal brain. Myelin receptors for cytokines. 4. N-Acetylaspartate and myelinogenesis.

S. Joseph Leibovich, Ph.D. * - Newark - Role of macrophages, nitric oxide and oxygen in regulation of angiogenesis in wound healing and cancer. Analysis of VEGF expression in macrophages and its regulation by nitric oxide. Role of ADP-ribosylation of VEGF in macrophages and its role in regulation of angiogenesis.

David M. Lukac, Ph.D. * - Newark - Molecular virology of Kaposi`s sarcoma-associated herpesvirus (HHV-8) in the pathogenesis of Kaposi`s sarcoma and primary effusion lymphoma.

Nicholas Megjugorac, Ph.D. * - Stratford - My work is currently focused on three aspects of the IL-17 axis of inflammation. (I) Defining the role of IFN-lambda on Th17 differentiation and cytokine expression. (II) Characterizing differences in IL-17 signaling in normal and malignant prostate cells. (III) Identifying mRNA expression profiles in the whole blood of patients with Inflammatory Bowel Disease. Email: N.Megjugorac@Humigen.org

Andrew R. Pachner, M.D. * - Newark - We focus on detection of pathogen and characterization of host immune response in infections of the nervous system, particularly Lyme borreliosis. We extensively use molecular biological tools, such as PCR and microarrays.

Sidney Pestka, M.D. * - Piscataway - Research involves the cloning of interferons and their receptors, and the development of new strategies for the treatment of viral diseases and cancers. The studies involve interferon and cell surface receptors and revolve around genetic engineering, protein biochemistry, signal transduction, immunology and gene therapy.

Nicholas M. Ponzio, Ph.D. * - Newark - Use of experimental models to study: (1) development and treatment of B cell lymphomas and leukemias, and (2) transplantation of umbilical cord blood in lieu of bone marrow for treatment of various diseases in which hematopoiesis is compromised.

Christine M. Rohowsky-Kochan, Ph.D. * - Newark - Studies focus on the nature and regulation of autoreactive T cells in multiple sclerosis and on the viral etiology of multiple sclerosis. Emphasis is on the role of cytokines and their control. Utilize immunological and molecular techniques.

Zoltan Spolarics, M.D., Ph.D. * - Newark - The project investigates the effects of genetic polymorphisms of metabolic enzymes and cytokines (IL-6, IL-10, IFN-γ) on the immune response. We employ genetically modified mice using experimental models of infection in vivo. We also investigate macrophage and T-cell responses in vitro. The human component of the project investigates the effects of genetic polymorphisms on the immune response in trauma patients. Infection, immunity, T-cells, macrophages, red blood cells, chemokines, polymorphism, flow cytometry, injury, host-response, malaria.

Kingsley Yin, Ph.D. * - Stratford - Research focuses on cytokines and other inflammatory mediators in sepsis. The role of Lipoxin A4 in macrophage function, resolving inflammation and mortality during sepsis is being investigated. The effects of Lipoxin A4 on the activity of the transcription factor -NF-kB, is also being established in sepsis. Email: yinki@umdnj.edu

Hua Zhu, Ph.D. * - Newark - My lab is studying cytomegalovirus, including host responses to viral infection, i.e. changes of signal transduction, and to understand how these responses influence viral replication and pathogenesis, and use microarray and mass spectrometry technologies to study viral and cellular gene expression.

* GSBS Faculty Return to Topics list

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