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GSBS Research Topics: CELL-CELL/CELL-MATRIX INTERACTION


Scott R. Diehl, Ph.D. * - Newark - Single Nucleotide Polymorphisms (SNPs) are analyzed to understand molecular causes of disease and individual differences in drug responses. High-throughput bioinformatics and complex statistical genetic methods are used for current research on oral cancer, periodontal disease, orofacial clefting; pharmacogenomics of pain and drug responses.

Gary, S. Goldberg, Ph.D. - Stratford - Cells must communicate with each other to coordinate the development and survival of an animal. This communication can be mediated by diffusible factors that pass between cells, or by direct contact through cell junctions. I am interested in how intercellular communication affects cell growth and differentiation, with an emphasis on how cell communication can control tumor cell growth and prevent eye diseases. Email: gary.goldberg@umdnj.edu

Andrew L. Harris, Ph.D. * - Newark - Connexins form intercellular pores through which ions and signaling molecules pass directly from cell to cell. These pores are important in signal transduction, tissue function, development and disease. Our studies explore, at the molecular level, mechanisms of selective molecular permeation, and mechanisms that regulate channel gating.

Michael B. Mathews, Ph.D. * - Newark - Double-stranded RNA binding proteins. Highly structured RNA is an important mediator of several processes, including gene expression and anti-viral defense mechanisms. We study the biochemical properties and biological roles of proteins that function as transcriptional and translational regulators.

Nicola C. Partridge, Ph.D. * - Piscataway - Parathyroid hormone signal transduction pathways regulating transcription of collagenase or stimulating osteoblast cell proliferation. Endocytotic receptors mediating the degradation of secreted collagenase. Mechanisms for enhancing the degradation of collagenase in osteoarthritic chondrocytes.

Biagio Saitto, Ph.D. * - Stratford - Our research program is focused on understanding molecular mechanisms involved in cell lineage differentiation potential of mesenchymal stem cells (MSCs) isolated from human cord blood. Using these adult stem cells, we are developing tissue-specific bioscaffolds for models of muscle injury repair. Email: saittabi@umdnj.edu

Andrew Singson, Ph.D. - Piscataway - The goal of research in the lab is to understand the molecular events that mediate sperm-egg interactions. The genetic and molecular dissection of these events will also provide insights relevant to other important cell-cell interactions in multicellular organisms.

Andrew P. Thomas, Ph.D. * - Newark - 1) Calcium-dependent signal transduction in response to hormones and growth factors, and 2) the effects of cocaine and alcohol on cardiac excitation-contraction coupling. We use digital imaging and laser scanning confocal microscopy to measure calcium and monitor organelle function in living cells; ion channel electrophysiology; molecular biology.

Ellen Townes-Anderson, Ph.D. * - Newark - Using primary cultures, we are trying to understand mechanisms of regeneration, degeneration, and synaptic plasticity in photoreceptors and other types of retinal neurons. Techniques used include microscopy, optical tweezers, time lapse recording, immunocytochemistry, and molecular biology.

William Wadsworth, * - Piscataway - Our laboratory is studying axon guidance and the development of the extracellular matrix. Using genetics and molecular biology techniques, we are discovering molecules that function to direct the formation of a nervous system. We use primarily the nematode C. elegans as a model organism.

Ian P. Whitehead , Ph.D. * - Newark - Our laboratory examines mammalian signal transduction and its relationship to cancer. More specifically, we utilize highly efficient, retroviral-based expression systems to identify and characterize oncogenes whose expression contribute to the metastatic potential of human breast tumors.

Mengqing Xiang, Ph.D. * - Piscataway - Our research interests center on understanding the molecular mechanisms that govern the determination and differentiation of the highly specialized sensory neurons. We employ molecular genetic approaches in animal models to identify and study transcription factors that are required for programming development of the retina, inner ear, and somatosensory ganglia.

Peter D. Yurchenco, M.D., Ph.D. * - Piscataway - Basement membranes are extracellular matrices that contribute to multiple steps of development and the maintenance of tissue function. Our current focus is on the molecular mechanisms underlying laminin-cell interactions and the relationship between laminin matrix-assembly and receptor activation.

Marco Zarbin, M.D., Ph.D. * - Newark - The laboratory research focuses on the development of treatments for retinal diseases such as age-related macular degeneration through ocular cell transplantation and the stimulation of retinal pigment epithelial wound healing.

James Zheng, Ph.D. * - Piscataway - We are interested in the molecular and cellular mechanisms underlying the precise wiring of the complex nervous system. Our current work focuses on the intracellular signaling pathway that allows developing axons to detect direction from environmental cues to reach their targets for specific neuronal connections.

* GSBS Faculty Return to Topics list


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