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GSBS Research Topics: CELL CYCLE/CELL DIFFERENTIATION


Subhasis, B. Biswas, Ph.D. * - Stratford - Our laboratory is interested in dissecting the mechanisms of DNA replication in prokaryotic and eukaryotic systems with goals of developing novel anti-microbials and anti-proliferation drugs. Email: biswassb@umdnj.edu

Salvatore J. Caradonna, Ph.D. * - Stratford - My laboratory is interested in the post-translational mechanisms that regulate proteins involved in base-excision repair of DNA. We are studying the aberrant pathways that lead to uracil misincorporation into DNA and strategies that may exploit these pathways for cancer drug development. We are also involved in the study of atypical cyclin-like proteins that affect cell-cycle phase transitions. Email: caradonn@umdnj.edu

Patrizia Casaccia-Bonnefil, M.D., Ph.D. * - Piscataway - Proliferation and differentiation of CNS precursor cells. Apoptosis mediated by death receptors in oligodendrocytes. Role of cell cycle inhibitors (p27,p21,p57) in CNS. Cancer. Multiple sclerosis. Stem Cells.

Frederick D. Coffman, Ph.D. * - Newark - Proteins and DNA sequences which regulate the initiation of DNA replication at human replication origins. We also examine the mechanism of tumor necrosis factor cytotoxicity and modulation of TNF sensitivity by antitumor drugs.

Katrina Cooper, Ph.D * - Stratford - Following stress cells have to orchestrate a myriad of responses to survive or die. Incorrect choices can lead to deleterious outcomes, e.g. tumor formation. To study this, we use S. cerevisiae, human cells and mouse models. We focus on the conserved cyclin C protein that is destroyed in response to stress and plays a role in apoptosis. Our working hypothesis is that cyclin C is a novel stress related tumor suppressor. Email: cooperka@umdnj.edu

Scott R. Diehl, Ph.D. * - Newark - Single Nucleotide Polymorphisms (SNPs) are analyzed to understand molecular causes of disease and individual differences in drug responses. High-throughput bioinformatics and complex statistical genetic methods are used for current research on oral cancer, periodontal disease, orofacial clefting; pharmacogenomics of pain and drug responses.

Stephen Garrett, Ph.D. * - Newark - We are interested in mechanisms of cell sensing. Our studies are carried out in the yeast Saccharomyces cerevisiae and are currently directed toward elucidating the function of the second messenger cAMP, as well as understanding the mechanism of manganese homeostasis.

Gary, S. Goldberg, Ph.D. - Stratford - Cells must communicate with each other to coordinate the development and survival of an animal. This communication can be mediated by diffusible factors that pass between cells, or by direct contact through cell junctions. I am interested in how intercellular communication affects cell growth and differentiation, with an emphasis on how cell communication can control tumor cell growth and prevent eye diseases. Email: gary.goldberg@umdnj.edu

Hristo Houbaviy, Ph.D. * - Stratford - We are interested in the roles of microRNAs in embryonic stem (ES) cells and during the early development of the mouse. Specifically, we are applying biochemical and mouse model approaches to elucidate the functions of miR-290-295 / miR-371-373 which appear to be ES cell and early embryo specific. Email: houbavhr@umdnj.edu

Lisa Huang, Ph.D. * - Stratford - My current research focuses on the identification of cancer biomarkers in the diagnosis and monitoring of cervical cancer, bladder cancer, and prostate cancer. Another of my research focuses on studying the mechanisms of DNA repair and drug resistance in bladder cancer and prostate cancer. These researches aid to assist in novel drug discovery. Email: lhuang@mdlab.com

Eldo, V. Kuzhikandathil, Ph.D. * - Newark - We are interested in the molecular analysis of dopamine receptor signaling mechanisms and their role in neurological diseases.Current research projects include structure-function analysis of dopamine receptors and the developmental regulation of dopamine receptor signaling pathways.

Michael Law, Ph.D. * - Stratford - Using S. cerevisiae as a model system, my work is aimed at determining how cell fate decisions are established. Differentiation requires temporal restrictions on transcription to be maintained. My work is interested in defining how post-translational protein modifications allow epigenetic regulation of transcriptional timing. Email: lawmj@umdnj.edu

Deborah, A. Lazzarino, Ph.D. * - Newark - Research studies in stem cell biology of the mammary gland in both normal and oncogenic development.

Robert W. Ledeen, Ph.D. * - Newark - 1. Ganglioside and sphingolipids in neuronal function: cell membrane and nuclear membrane. 2. Gangliosides as modulators of flux and signaling. 3. Myelin metabolism in multiple sclerosis and normal brain. Myelin receptors for cytokines. 4. N-Acetylaspartate and myelinogenesis.

Steven W Levison, Ph.D. * - Newark - The goal of Dr. Levisonís research is to enhance regeneration of the CNS from its resident stem cells and to understand the impact of neuroinflammation using cell culture and animal models of multiple sclerosis, neonatal hypoxia ischemia, traumatic brain injury and stroke.

Michael P. Matise, Ph.D. * - Piscataway - Research in the lab is directed at elucidating the molecular mechanisms controlling neurogenesis in the developing central nervous system, with an emphasis on the vertebrate (mouse, chick) spinal cord.

Kim S. McKim, Ph.D. * - Piscataway - My laboratory is characterizing genes with important roles in either meiotic recombination or segregation of chromosomes using Drosophila melanogaster as a model system. Many of these genes are also involved in DNA repair and we are characterizing their functions during Drosophila development.

Carlos A. Molina, Ph.D. * - Newark - We are interested in the regulation of gene expression during the cell cycle by the tumor suppressor and transcriptional repressor, Inducible cAMP Early Repressor (ICER). Circadian rhythm.

Eric G. Moss, Ph.D. * - Stratford - We study developmental timing, microRNAs and translational control in C. elegans and the mouse. The worm heterochronic gene lin-28 is regulated by microRNAs and encodes a specific mRNA-binding protein. Its human homologue, Lin28, appears also to be a microRNA-controlled developmental regulator. Email: mosseg@umdnj.edu

Susan Muller-Weeks, Ph.D. * - Stratford - Research in the laboratory focuses on the repair of uracil in DNA, which is critical for the maintenance of genomic integrity. Specifically we are elucidating transcriptional and post-translational pathways that regulate expression of uracil-DNA glycosylase under normal cellular conditions and in response to anti-tumor agents. Email: muller@umdnj.edu

Joseph Nickels, Ph.D. * - Stratford - Our research uses proteomic/genomic methods and mouse models to understand the biology of diseases, such as cancer initiation and metastasis, cardiovascular disease, and infectious mycoses. Our goal is discovering novel genes that can be used as biomarkers and drug targets, thus allowing us to diagnose and treat these diseases. Email: jnickels@mdlab.com

Harvey Ozer, M.D. * - Newark - Carcinogenesis and Regulation of Cellular Aging. We have been studying human diploid fibroblasts (HF) and introduction of genes from the DNA tumor virus SV40 to understand the mechanism of multi-step carcinogenesis ("transformation") in culture and its effect on bypassing cellular aging and facilitating immortalization.

Nicola C. Partridge, Ph.D. * - Piscataway - Parathyroid hormone signal transduction pathways regulating transcription of collagenase or stimulating osteoblast cell proliferation. Endocytotic receptors mediating the degradation of secreted collagenase. Mechanisms for enhancing the degradation of collagenase in osteoarthritic chondrocytes.

Garth I. Patterson, Ph.D. * - Piscataway - We study a TGF-beta pathway that controls C. elegans larval development. We wish to learn how this pathway controls a neuroendocrine signal, as well as how this signal is transduced.

Dimitri G. Pestov, PhD * - Stratford - We study the mechanisms of ribosome biogenesis in mammalian cells in connection with regulation of cell growth and proliferation. Our major goal is to understand how the accuracy of ribosome assembly is controlled at the molecular level and how defects in this process contribute to human disease. Email: pestovdg@umdnj.edu

Lyndi Rice, Ph.D. * - Stratford - The focus of our group is to elucidate the molecular regulation of several tumor suppressors and oncogenes in the onset of gynecological cancers, using cell culture, primary tissues, and mouse model systems. Through our research, we will identify novel biomarkers to aid in early detection and potential drug targets that modulate tumor progression. Email: lrice@mdlab.com

Randy Strich, Ph.D. * - Stratford - Our laboratory focuses on understanding how the transcription program is coupled to meiotic progression in budding yeast. A second project investigates the activity of the conserved C-type cyclin in directing the oxidative stress response and apoptosis in yeast and mammalian systems. Email: strichra@umdnj.edu

George P. Studzinski, M.D.,Ph.D. * - Newark - With the objective of advancing cancer chemotherapy options,we are studying the mechanisms of induction of mature monocytic phenotype and cell cycle arrest in human myeloid leukemia cells(HL60,U937,etc).Analogs of vitamin D are principal inducing agents,and MAPK and PI3K pathways are the current focus.

Jason Trama, Ph.D. * - Stratford - Our laboratory uses proteomic and genomic data to identify biomarkers for gynecologic and urologic cancers. Our goal is to develop noninvasive methods for diagnosis and monitoring. We also study the mechanisms of tumorigenesis, metastasis and drug resistance in order to identify targets for therapy. Email: jtrama@mdlab.com

B.J. Wagner, Ph.D. * - Newark - Role of the ubiquitin-proteasome pathway in development, aging and response to stress: We use the mammalian ocular lens and lens cell culture models to study differentiation, cataractogenesis and oxidative stress.

Nancy Walworth, Ph.D. * - Piscataway - Studies on cell cycle checkpoints: signal transduction pathways that control cell cycle progression in response to DNA damage or DNA replication blocks, using the genetically tractable fission yeast, Schizosaccharomyces pombe as a model system. Checkpoint defects are apparent in cells of patients with the cancer-prone genetic disorder ataxia telangiectasia (AT).

Lizhao Wu, Ph.D. * - Newark - We use a combination of molecular, cellular, and genetic approaches to identify key molecules that are important for cancer. Both cell culture systems and mouse models are used to delineate various tumor suppressor/oncogenic pathways in the hematopoietic system, prostate gland, and mammary gland.

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