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GSBS Research Topics: CARDIOVASCULAR


Gopal, J Babu, Ph.D. * - Newark - Sarcoplasmic reticulum Calcium ATPase (SERCA) play an important role in cardiac function in health and disease. My lab is interested in studying the role of sarcolipin, a regulator of cardiac SERCA pump in atrial arrhythmogenesis.

Gary Brewer, Ph.D. * - Piscataway - Identification and analyses of cis- and trans-acting factors controlling mRNA decay in cancer, heart disease and immune responses.

Scott R. Diehl, Ph.D. * - Newark - Single Nucleotide Polymorphisms (SNPs) are analyzed to understand molecular causes of disease and individual differences in drug responses. High-throughput bioinformatics and complex statistical genetic methods are used for current research on oral cancer, periodontal disease, orofacial clefting; pharmacogenomics of pain and drug responses.

Walter N. Duran, Ph.D. * - Newark - Signaling between the vascular wall and blood cells: 1) role of NOS in hyperpermeability induced by inflammatory agents; 2) signaling pathways in the control of permeability 3) permeability alterations associated with microvascular dysfunction. We use intravital microscopy, computer-assisted image analysis, Western blotting, and reverse transcriptase PCR.

Jonathan Foulds, Ph.D. - Piscataway - Tobacco addiction, smoking cessation, health effects of tobacco, tobacco dependence treatment, psychological and behavioural effects of nicotine and nicotine withdrawal.

Carl Hock, Ph.D. * - Stratford - Current work is focused on the effect of humoral mediators and inflammatory cells in the pathophysiology of ischemic states, the effects of dietary lipids on cardiovascular function and the response of the young and aging heart to ischemia and reperfusion. Email: hock@umdnj.edu

Hieronim Jakubowski, Ph.D. * - Newark - tRNA-synthetases establish the rules of the genetic code by matching amino acids with cognate tRNAs. We study: 1) accuracy of tRNA-synthetases in protein synthesis, including editing, 2)the role of homocysteine incorporation into protein(protein N-homocysteinylation) in cardiovascular disease.

Joseph Kedem, Ph.D. * - Piscataway - Relationship between local myocardial function and energy metabolism. Effects of various types of ischemic damage on efficiency of cardiac contraction. In vivo experiments and mathematical analyses.

S. Joseph Leibovich, Ph.D. * - Newark - Role of macrophages, nitric oxide and oxygen in regulation of angiogenesis in wound healing and cancer. Analysis of VEGF expression in macrophages and its regulation by nitric oxide. Role of ADP-ribosylation of VEGF in macrophages and its role in regulation of angiogenesis.

Pranela Rameshwar, * - Newark - Hematopoiesis: homeostasis vs. dysfunction

John P. Reeves, Ph.D. * - Newark - The Na/Ca exchange system is the principal Ca efflux mechanism in cardiac muscle cells and plays an important role in regulating cardiac contractility. We study the cellular mechanisms that control the activity of this important transporter using molecular and Ca imaging techniques.

Hreday N. Sapru, Ph.D. * - Newark - Central control of cardiovascular and respiratory functions. Neural circuits and transmitters involved in different reflex mechanisms (e.g., baroreflex, chemoreflex, cardiopulmonary reflex). Alterations of these control mechanisms in pathological states (e.g., hypertension, global cerebral ischemia, adult respiratory distress syndrome).

Roman Shirokov, Ph.D. * - Newark - Ca channels interface membrane excitability and Ca signaling. We study their inactivation, or spontaneous disabling closure. We measure ionic and gating currents, intracellular Ca signals. We use molecular engineering and bioinformatics to define the structure and interactions of the parts involved.

Andrew P. Thomas, Ph.D. * - Newark - 1) Calcium-dependent signal transduction in response to hormones and growth factors, and 2) the effects of cocaine and alcohol on cardiac excitation-contraction coupling. We use digital imaging and laser scanning confocal microscopy to measure calcium and monitor organelle function in living cells; ion channel electrophysiology; molecular biology.

Nancy, A. Woychik, Ph.D. * - Piscataway - RNA polymerases and transcription regulation in cancer and other diseases; Alterations in host cell transcription upon smallpox virus infection; Transcription mechanisms important for Chlamydia pathogenesis; Chlamydia infection and heart disease.

* GSBS Faculty Return to Topics list


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