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GSBS Research Topics: CALCIUM

Joshua R. Berlin, Ph.D. * - Newark - Voltage-dependent reaction steps in ion transport using the Na,K-ATPase as a model system. Ion transport kinetics are measured by patch-clamp in cardiac myocytes and HeLa cells expressing Na,K-ATPase enzymes containing point mutations. We also are studying Cardiac muscle excitation-contraction coupling and calcium influx.

Sylvia Christakos, Ph.D. * - Newark - The Vitamin D Endocrine System:Function and Regulation. Bone.

Carl J. Hauser, M.D. - Newark - My laboratory studies neutrophil functional responses in the inflammatory cytokine milieu generated by trauma. We have a special interest in the cross regulation of G-protein coupled receptors and the mechanisms of their mobilization of cell calcium under such conditions.

Eldo, V. Kuzhikandathil, Ph.D. * - Newark - We are interested in the molecular analysis of dopamine receptor signaling mechanisms and their role in neurological diseases.Current research projects include structure-function analysis of dopamine receptors and the developmental regulation of dopamine receptor signaling pathways.

Robert W. Ledeen, Ph.D. * - Newark - 1. Ganglioside and sphingolipids in neuronal function: cell membrane and nuclear membrane. 2. Gangliosides as modulators of flux and signaling. 3. Myelin metabolism in multiple sclerosis and normal brain. Myelin receptors for cytokines. 4. N-Acetylaspartate and myelinogenesis.

Joseph McArdle, Ph.D. * - Newark - Electrophysiologic techniques are used to explore the physiologic/pharmacologic properties of ligand-gated ion channels on native cells at various developmental stages as well as during pathologic conditions. Pharmacologic manipulations are used to test the importance of a receptor to the development or time course of a pathologic state.

Martha C. Nowycky, Ph.D. * - Newark - We study voltage-gated calcium channels and the TRP family channels, using patch clamp, digitial imaging, and molecular biology techniques. We examine the links between neurotransmitter and hormone stimulation, signal transduction via G-proteinsand calcium stores in neurons and excitable cells.

Nicola C. Partridge, Ph.D. * - Piscataway - Parathyroid hormone signal transduction pathways regulating transcription of collagenase or stimulating osteoblast cell proliferation. Endocytotic receptors mediating the degradation of secreted collagenase. Mechanisms for enhancing the degradation of collagenase in osteoarthritic chondrocytes.

John P. Reeves, Ph.D. * - Newark - The Na/Ca exchange system is the principal Ca efflux mechanism in cardiac muscle cells and plays an important role in regulating cardiac contractility. We study the cellular mechanisms that control the activity of this important transporter using molecular and Ca imaging techniques.

Roman Shirokov, Ph.D. * - Newark - Ca channels interface membrane excitability and Ca signaling. We study their inactivation, or spontaneous disabling closure. We measure ionic and gating currents, intracellular Ca signals. We use molecular engineering and bioinformatics to define the structure and interactions of the parts involved.

Andrew P. Thomas, Ph.D. * - Newark - 1) Calcium-dependent signal transduction in response to hormones and growth factors, and 2) the effects of cocaine and alcohol on cardiac excitation-contraction coupling. We use digital imaging and laser scanning confocal microscopy to measure calcium and monitor organelle function in living cells; ion channel electrophysiology; molecular biology.

Ellen Townes-Anderson, Ph.D. * - Newark - Using primary cultures, we are trying to understand mechanisms of regeneration, degeneration, and synaptic plasticity in photoreceptors and other types of retinal neurons. Techniques used include microscopy, optical tweezers, time lapse recording, immunocytochemistry, and molecular biology.

Venkat Venkataraman, Ph.D * - Stratford - We are investigating the processes of neuronal transduction in biological clocks and aging with respect to the role of Ca2+ signaling via alpha2 adrenergic receptors and membrane guanylate cyclases. Email: venkatar@umdnj.edu

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