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GSBS Research Topics: BIOINFORMATICS


Bharat Biswal, Ph.D. - Newark - Medical imaging including Magnetic Resonnce Imaging (MRI) and Functional MRI, and Laser Doppler Imging. Primarily interest is in devlopment of signal/image processing techniques to better understand the signal measured and increase its application for use in basic science and clinical application.

Gill Diamond, Ph.D. * - Newark - Studies on the molecular biology and mechanisms controlling expression of antimicrobial peptides, especially under conditions of injury, stress and infection. These peptides are found in phagocytic cells and mucosal tissues and may help us better understand host defense mechanisms. Antibiotics.

Scott R. Diehl, Ph.D. * - Newark - Single Nucleotide Polymorphisms (SNPs) are analyzed to understand molecular causes of disease and individual differences in drug responses. High-throughput bioinformatics and complex statistical genetic methods are used for current research on oral cancer, periodontal disease, orofacial clefting; pharmacogenomics of pain and drug responses.

David, J. Foran, Ph.D. * - Piscataway - Research focuses on statistical pattern recognition, evolutionary computing, data fusion and intelligent databases as they relate to automated image interpretation, computer-assisted diagnosis, and bioinformatics.

Gary, S. Goldberg, Ph.D. - Stratford - Cells must communicate with each other to coordinate the development and survival of an animal. This communication can be mediated by diffusible factors that pass between cells, or by direct contact through cell junctions. I am interested in how intercellular communication affects cell growth and differentiation, with an emphasis on how cell communication can control tumor cell growth and prevent eye diseases. Email: gary.goldberg@umdnj.edu

Richard D. Howells, Ph.D. * - Newark - Molecular analysis of opioid receptor structure and function. Opioid receptors are G protein-coupled receptors on the cell surface of neurons that mediate signal transduction pathways activated by endogenous opioid peptides and opiate drugs, such as morphine. Molecular consequences of opioid addiction are being investigated via gene arrays and proteomics.

John, E. Kerrigan, Ph.D. * - Piscataway - Our research efforts are aimed toward the identification of novel small molecule therapetics for the treatment of cancer and other diseases using de novo computational methods. Molecular modeling of protein and dna complexes with potential drug leads is applied.

Hong Li, Ph.D. * - Newark - Center for Advanced Proteomics Research is located in MSB F602 at NJMS. This facility is equipped with state-of-the-art proteomics instruments and bioinformatics systems for protein structure and function analysis. We have a Micromass QTOF mass spectrometer and an ABI 4700 Proteomics Analyzer.

Michael B. Mathews, Ph.D. * - Newark - Double-stranded RNA binding proteins. Highly structured RNA is an important mediator of several processes, including gene expression and anti-viral defense mechanisms. We study the biochemical properties and biological roles of proteins that function as transcriptional and translational regulators.

Joseph I. Naus, Ph.D. * - Piscataway - Bioinfomatics, computational molecular biology. Significant multiple matching in DNA and protein sequences, scan statistics, unusual clustering, including temporal and spatial clustering of disease. Data Editing.

Wilma K. Olson, Ph.D. * - Piscataway - Theoretical and computational studies of the relationship of chemical architecture to the conformation, properties and interactions of biological macromolecules, with major emphasis on nucleic acids.

Narayanan Ramasubbu, Ph.D. - Newark - Structural biology of proteins that impact oral diseases and biofilms.

Lynn S. Ripley, Ph.D. * - Newark - Studies in the lab focus on frameshift mutagenesis mechanisms, especially how enzymes go wrong. Special emphasis is on spontaneous mutations in vitro, in model prokaryotic systems and the mutations responsible for human disease (both germline and somatic).

Melissa B. Rogers, Ph.D. * - Newark - Retinoids control cell cycle, apoptosis, & differentiation. We study how retinoic acid controls key genes like BMP-2. We use enhancer traps to isolate RA response elements. Our functional genomics approach should identify RA-regulated genes that initiate critical signaling cascades in development.

Roman Shirokov, Ph.D. * - Newark - Ca channels interface membrane excitability and Ca signaling. We study their inactivation, or spontaneous disabling closure. We measure ionic and gating currents, intracellular Ca signals. We use molecular engineering and bioinformatics to define the structure and interactions of the parts involved.

* GSBS Faculty Return to Topics list


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