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GSBS Research Topics: APOPTOSIS

Patrizia Casaccia-Bonnefil, M.D., Ph.D. * - Piscataway - Proliferation and differentiation of CNS precursor cells. Apoptosis mediated by death receptors in oligodendrocytes. Role of cell cycle inhibitors (p27,p21,p57) in CNS. Cancer. Multiple sclerosis. Stem Cells.

Sylvia Christakos, Ph.D. * - Newark - The Vitamin D Endocrine System:Function and Regulation. Bone.

Frederick D. Coffman, Ph.D. * - Newark - Proteins and DNA sequences which regulate the initiation of DNA replication at human replication origins. We also examine the mechanism of tumor necrosis factor cytotoxicity and modulation of TNF sensitivity by antitumor drugs.

Katrina Cooper, Ph.D * - Stratford - Following stress cells have to orchestrate a myriad of responses to survive or die. Incorrect choices can lead to deleterious outcomes, e.g. tumor formation. To study this, we use S. cerevisiae, human cells and mouse models. We focus on the conserved cyclin C protein that is destroyed in response to stress and plays a role in apoptosis. Our working hypothesis is that cyclin C is a novel stress related tumor suppressor. Email: cooperka@umdnj.edu

Ronald Ellis, Ph.D. * - Stratford - Control of Germ Cell Fate: Animals must produce sperm or eggs to reproduce. Although these cell types differ dramatically, they are produced from similar progenitors. Understanding how this process is controlled could revolutionize our ability to treat reproductive disorders and infertility in humans. Evolution of Hermaphroditism: Sexual traits are among the most rapidly changing features of each species. To learn how these changes take place, and how developmental pathways constrain which ones occur, we are studying the evolution of mating systems in nematodes. Email: ellisre@umdnj.edu

Celine Gelinas, Ph.D. * - Piscataway - The Rel/NF-kB transcription factors play fundamental roles in immune and inflammatory responses, and are implicated in many human hematopoietic and solid cancers. Our research aims at understanding their effects on cellular gene expression, cell growth control, apoptosis and oncogenesis.

Lisa Huang, Ph.D. * - Stratford - My current research focuses on the identification of cancer biomarkers in the diagnosis and monitoring of cervical cancer, bladder cancer, and prostate cancer. Another of my research focuses on studying the mechanisms of DNA repair and drug resistance in bladder cancer and prostate cancer. These researches aid to assist in novel drug discovery. Email: lhuang@mdlab.com

Robert W. Ledeen, Ph.D. * - Newark - 1. Ganglioside and sphingolipids in neuronal function: cell membrane and nuclear membrane. 2. Gangliosides as modulators of flux and signaling. 3. Myelin metabolism in multiple sclerosis and normal brain. Myelin receptors for cytokines. 4. N-Acetylaspartate and myelinogenesis.

Barry E. Levin, M.D. * - Newark - How the brain senses, integrates and regulates metabolic systems controlling energy homeostasis in obesity and in diabetes. Emphasis on diet-induced obesity, neural glucosensing, hypoglycemia-induced brain damage. Utilize behavioral, neurochemical, molecular and physiologic techniques.

Leroy F. Liu, Ph.D. * - Piscataway - Roles of topoisomerases mediating genome instability, carcinogenesis and tumor cell death investigated. Three areas are: a) Topoisomerase I a new molecular target for anticancer drugs. b) Repair topoisomerase I-mediated DNA damage. c) Role of topoisomerase II in tumor cell death and carcinogenesis.

David M. Lukac, Ph.D. * - Newark - Molecular virology of Kaposi`s sarcoma-associated herpesvirus (HHV-8) in the pathogenesis of Kaposi`s sarcoma and primary effusion lymphoma.

Stuart G. Lutzker, M.D., Ph.D. * - Piscataway - My lab examines the role of the p53 transcription factor in the cellular response to DNA damage. We have developed a unique genetic system to test the role of specific post-translational modifications in fine-tuning the p53 response.

Carlos A. Molina, Ph.D. * - Newark - We are interested in the regulation of gene expression during the cell cycle by the tumor suppressor and transcriptional repressor, Inducible cAMP Early Repressor (ICER). Circadian rhythm.

Catherine Neary, Ph.D. * - Stratford - Hexokinase II (HK2), which catalyzes the first committed step of glycolysis, is overexpressed in many cancers. When inhibited, HK2 translocates from the mitochondria to the nucleus. I am investigating the signaling pathways that mediate HK2 mitochondrial association and nuclear translocation. Email: nearycl@umdnj.edu

Harvey Ozer, M.D. * - Newark - Carcinogenesis and Regulation of Cellular Aging. We have been studying human diploid fibroblasts (HF) and introduction of genes from the DNA tumor virus SV40 to understand the mechanism of multi-step carcinogenesis ("transformation") in culture and its effect on bypassing cellular aging and facilitating immortalization.

John Pastorino, PhD * - Stratford - Our work identifies distinctions in mitochondrial function between normal and cancerous cells for the potential discovery of novel chemotherapeutic targets that can be exploited to selectively induce cytotoxicity in cancer cells. Mitochondrial injury is also central to number of disease states. Email: pastorjg@umdnj.edu

Yufang Shi, Ph.D., D.V.M. * - Piscataway - We are interested in understanding the role of apoptosis in regulating immune responses. The mechanisms controlling FASL, TRAIL, RANKL and TNF expression in T cells are the main focus. We are also studying psychoneuroimmunology, especially the effects of stress and opioids on the immune system.

C.K. Suzuki, Ph.D. * - Newark - My lab focuses on the function of molecular chaperones and ATP-dependent proteases in mitochondrial biogenesis and mitochondrial-dependent apoptosis.

Jason Trama, Ph.D. * - Stratford - Our laboratory uses proteomic and genomic data to identify biomarkers for gynecologic and urologic cancers. Our goal is to develop noninvasive methods for diagnosis and monitoring. We also study the mechanisms of tumorigenesis, metastasis and drug resistance in order to identify targets for therapy. Email: jtrama@mdlab.com

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