Graduate School of
Guillermina (Gigi) Lozano, Ph.D.
Professor and Chair
Department of Genetics
The University of Texas MD Anderson Cancer Center.
BS Magna cum laude, Pan American University
PhD, Rutgers University and UMDNJ
Post-Doc, Princeton University
Dr. Lozano directs a research laboratory that studies the p53 tumor suppressor pathway. To grow, most tumors must inactivate this pathway. Her contributions include the identification of the tumor suppressor p53 as a transcriptional activator, the finding that p53 missense mutations commonly observed in cancers were transcriptionally inactive, and the identification of the Mdm proteins as critical inhibitors of p53. She has published over 170 peer-reviewed articles, journal reviews and book chapters, and is currently the Principle Investigator on several grants including a Training Grant from the National Cancer Institute. Dr. Lozano also chairs the Department of Genetics.
Raycroft L, Wu HY, Lozano G. Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. Science 249(4972):1049-1051, 1990.
Montes de Oca Luna R, Wagner DS, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378(6553):203-206, 1995.
Parant J, Chavez-Reyes A, Little NA, Yan W, Reinke V, Jochemsen AG, Lozano G. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet 29:92-95, 2001.
Lang GA, Iwakuma T, Suh YA, Liu G, Rao VA, Parant JM, Valentin-Vega YA, Terzian T, Caldwell LC, Strong LC, El-Naggar AK, Lozano G. Gain-of-function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell 119(6):861-872, 2004.
Post SM, Quintas-Cardama A, Pant V, Iwakuma T, Hamir A, Jackson JG, Maccio DR, Bond GL, Johnson DG, Levine AJ, Lozano G. A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development. Cancer Cell 18(3):220-230, 2010.
Awards and Honors
1992 Distinguished Alumnus Award, The University of Texas Pan American
2004 Mattie Allen Fair Research Chair, The University of Texas MD Anderson Cancer Center
2011 Fellow, American Association for the Advancement of Science
2011 Minorities in Cancer Research Jane Cooke Wright Lectureship, American Association for Cancer Research